2011 Fiscal Year Final Research Report
Study of epigentic mechanism underlying age-related hearing loss
| Project/Area Number |
21791659
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | 独立行政法人国立病院機構東京医療センター(臨床研究センター) (2011)
独立行政法人国立病院機構(東京医療センター臨床研究センター) (2009-2010) |
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Principal Investigator |
MUTAI Hideki 独立行政法人国立病院機構東京医療センター(臨床研究センター), 聴覚平衡覚研究部, 研究員 (60415891)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 耳科学 |
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| Research Abstract |
Auditory function is important for social communication. This study revealed evidence of epigenetic regulatory mechanism in rodent and primate auditory sensory epithelia. In DBA/2J, a mouse model of progressive/age-related hearing loss, several genes were found to change the genomic methylation levels as well as transcritpion levels in the auditory epithelium during progress of hearing loss. Treatment of the animals with drugs to modfy epigenetic mechanism successfully attenuated the progress of hearing loss.
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