2010 Fiscal Year Final Research Report
Role of heat-shock proteins in the ocular immune privilege
| Project/Area Number |
21791671
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKASE Hiroshi Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (20451940)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 免疫学 / 眼科 / 炎症 |
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| Research Abstract |
The present study was aimed at investigating the role of heat-shock proteins (HSPs) in the immune regulation in the eye. We hypothesized that the intraocular fluids contain secreted form of HSPs, and that the HSPs act as antigens targeted by ocular infiltrating cells, or as immune suppressive agents. We first tested if aqueous humor from patients with cataract contain HSPs. We detected HSP27 in the aqueous humor, whereas HSP10, HSP60, or HSP70 were not detected. We then co-cultured recombinant HSP27 with T cell clones (TCCs) and tested if HSP27 has effects on the proliferation or cytokine production of TCCs. As a result, HSP27 up-regulated interferon-gamma production by TCCs.
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Research Products
(1 results)
