2010 Fiscal Year Final Research Report
Regulatory mechanisms of neuronal regeneration in the retina and role of the pars plana.
| Project/Area Number |
21791676
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
NISHIGUCHI Koji Nagoya University, 医学部附属病院, 助教 (30447825)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ヘパラン硫酸 / 血管内皮成長因子 / 糖尿病網膜症 |
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| Research Abstract |
The high concentration of heparan sulfate found in the intraocular fluid binds to various growth factors and cytokines including vascular endothelial growth factor through heparin-binding domain and thereby inhibits their physiological function. This mechanism proved to inhibit the aberrant invasion of pathological retinal vessels into the vitreous. Furthermore, intraocular heparan sulfate may regulate the development of retinal tissue including the vascular network.
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