2010 Fiscal Year Final Research Report
Development of detecting retinal ganglion cell response using electroretinogram
| Project/Area Number |
21791678
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
UENO Shinji Nagoya University, 医学部附属病院, 助教 (80528670)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ERG / retinal ganglion cell / PhNR |
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| Research Abstract |
We studied detecting retinal ganglion cell response using ERG in animal models. We detected scotopic threshold response (STR) from -7.2 log cd s m^2 to -4.2 log cd s m^2. The amplitude of STR significantly decreased after optic nerve injury. These results indicated STR is originated from retinal ganglion cells. We also checked mouse photopic negative response (PhNR), which is supposed to be originated from retinal ganglion cells in primate. But our results did not show significant reduction of PhNR after tetrodotoxin injection in mouse eye. This result indicated PhNR of mouse is not useful to detect mouse retinal ganglion cell response. Rabbit ERG showed reduction of PhNR after TTX injection and these data showed PhNR of rabbit eye consisted of retinal ganglion cell function. The origin of PhNR may be different among animal species.
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