2010 Fiscal Year Final Research Report
Development of treatment for skin wound which controlled TGF beta/Smad signal.
| Project/Area Number |
21791775
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KIDA Maki Wakayama Medical University, 医学部, 助教 (00326381)
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| Project Period (FY) |
2009 – 2010
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| Keywords | オステオポンチン / TGFβ / 皮膚創傷治癒 / 線維化 |
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| Research Abstract |
Lucking OPN suppressed granulation tissue fomation, the expression of macrophage and extracellular matrix. Moreover, the expression of phosphor Smad2 was reduced in vitro. Loss of osteopontin(OPN), TGF beta/Smad signal was controlled during skin wound healing. As a result, it was suggested that the expression of extracellular matrix was controlled in a condition of lucking OPN.
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