2010 Fiscal Year Final Research Report
Effect of diet-induced obesity and its immuno-defect on sublingual immunotherapy.
| Project/Area Number |
21791781
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
NAGAI Yasuhiro Tohoku University, 大学院・歯学研究科, 助教 (90508962)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 免疫 / 肥満 / アレルギー / 舌下免疫 |
|---|
| Research Abstract |
Evidence from population studies shows that obesity clearly exacerbates a health risk. In this study we investigated the effects of diet-induced obesity on nickel allergy and anaphylactic shock and obtained the results below ; 1. Diet-induced obesity significantly reduced nickel allergy reaction. 2. Sublingual immunotherapy significantly reduces nickel allergy in normal mice, but there is no difference in obesity mice. OVA-induced anaphylactic shock did not occur in obesity mice.
|
