2010 Fiscal Year Final Research Report
Role of retinoic acid catabolising enzyme in craniofacial development
| Project/Area Number |
21791785
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
ABE Makoto Osaka University, 歯学研究科, 助教 (40448105)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔解剖学 / 口腔顔面発生 / レチノイン酸 / Trps1 |
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| Research Abstract |
In order to understand the molecular mechanisms of normal craniofacial development, microarray analysis was performed using pharyngeal arches from wild type and Cyp26B1 knockout embryos. Number of molecules was identified to be up- or down-regulated. Trps1 was one of the molecules those were down-regulated in Cyp26B1 knockout mice. Trps1 knockout mice showed craniofacial deformities partially overlapping the defects observed in Cyp26B1 knockout mice.
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