2010 Fiscal Year Final Research Report
バクテロデスフィラムに位置する細菌の菌体外蛋白質分泌機構の解明
Project/Area Number |
21791793
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Morphological basic dentistry
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Research Institution | Nagasaki University |
Principal Investigator |
SATO Keiko Nagasaki University, 医歯薬学総合研究科, 助教 (70410579)
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Project Period (FY) |
2009 – 2010
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Research Abstract |
Porphyromonas gingivalis is an oral anaerobic Gram-negative bacterium, which is implicated in periodontal pathogenesis. Most of proteolytic activity of extracellular and cell-surface proteinase are derived from cysteine proteinase named gingipains. We found a novel protein secretion system in bacteria of the phylum Bacteroidetes, which is responsible for secretion of virulence factors such as gingipain proteinases produced from the periodontal pathogen Porphyromonas gingivalis and is linked to bacteroidete gliding motility that is distinct from other well-studied forms of bacterial movement.
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[Journal Article] Characterization of hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis: its cellular distribution, thioredoxin activity and role in heme utilization(共著)2010
Author(s)
hoji M, Shibata Y, Shiroza T, Yukitake H, Peng B, Chen Y-Y, Sato K, Naito M, Abiko Y, Reynolds EC, Nakayama K
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Journal Title
BMC Microbiology 10巻
Pages: 152
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[Remarks] ホームページ等