Elucidation of Toll-like receptor mediated immune activation effects induced by oral gram-positive bacteria

2011 Fiscal Year Final Research Report

• Project/Area Number: 21791796
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Showa University
• Principal Investigator: KATAOKA Hideo 昭和大学, 歯学部, 助教 (60451390)
• Project Period (FY): 2009 – 2011
• Keywords: 口腔細菌学

Research Abstract

It has not been shown the detail molecular mechanisms of inducing periodontal inflammation by oral gram-positive bacteria. In this study, we showed a molecular mechanism that bacterial lipoproteins of Oral Streptococci and Actinomyces induce inflammatory responses via Toll-like receptor 2 in host cells. This finding suggests that these bacterial lipoproteins could be an inducing factor of periodontal inflammation.

Research Products

• [Journal Article] Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages (2012)
  • Author(s): Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T
  • Journal Title: Microbes and Infection Volume: (In press)
  • DOI: DOI:10.1016/j.micinf.2012.04.015
  • Peer Reviewed
• [Presentation] Lipoproteins of human cariogenic bacteria are responsible for inflammation-inducing activity mediated by Toll-like receptor 2 (2009)
  • Author(s): Kataoka H, Takahashi M, Shibata Y, Igarashi T
  • Organizer: 3^<rd> Congress of European Microbiologists
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 20090628-0702