2011 Fiscal Year Final Research Report
Regenerative effects of statin and MTA on teeth and periodontal tissue.
| Project/Area Number |
21791862
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORIUCHI Noboru 奥羽大学, 歯学部, 教授 (00107294)
KATO Yasumasa 奥羽大学, 歯学部, 教授 (50214408)
KIMURA Yuichi 奥羽大学, 歯学部, 教授 (60211877)
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| Project Period (FY) |
2009 – 2011
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| Keywords | MTAセメント / スタチン |
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| Research Abstract |
Mineral trioxide aggregate and statins strongly induce mineralization in osteoblasts and stem cells. MTA promoted the gene expression of alkaline phosphatase and osteopontin and enhanced alkaline phosphatase activity throughout the culture period, whereas it markedly inhibited the gene expression of type I collagen. In this study, promoted mineralization of statins, was not strong compared with MTA. However, statin stimulated osteoblastic differentiation while inhibited adipocyte differentiation.
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Research Products
(9 results)
