2010 Fiscal Year Final Research Report
siRNA therapy targeting DIF・PDE1 signal transduction pathway on human malignant melanoma
| Project/Area Number |
21791986
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Mie University |
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Principal Investigator |
SHIMIZU Kasumi Mie University, 医学部附属病院, 助教 (20378368)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Phosphodiesterase / 悪性黒色腫 |
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| Research Abstract |
We analyzed the effect of PDE1A siRNA and PDE1C siRNA for human malignant melanoma cell migration. Both of them increased cell migration slightly. And, PDE1 did not relate apoptosis. But, PDE2 related the DNA synthesis and it suggested that PDE2 may regulates the cell cycle. Furthermore, PDE1 specific inhibitor inhibits the expression of MMP2, but did not inhibit expression of MMP3 and MMP8.
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