2010 Fiscal Year Final Research Report
A development of new treatment for oral cancer with beta4 integrin and associated proteins.
| Project/Area Number |
21792011
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
ARAMOTO Takayoshi Ehime University, 医学部附属病院, 助教 (00380220)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | beta4 integrin / ヘミデスモゾーム / siRNA |
|---|
| Research Abstract |
We concluded that the inhibition of beta4 integrin which is the member of integrin family, can interaction with ECM, changed cell morphology, cell motility, and decreased cell invation in oral squamous cell lines. Our data suggested that beta4 integrin is greatly taken part in cancer cell invation.
|
