2010 Fiscal Year Final Research Report
Expression analysis of SFRP family genes for development of molecular targeted therapy for oral cancer
| Project/Area Number |
21792021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SOGABE Yohei Sapporo Medical University, 医学部, 研究員 (50468104)
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| Co-Investigator(Renkei-kenkyūsha) |
OGI Kazuhiso 札幌医科大学, 医学部, 助教 (40433114)
HIRATSUKA Hiroyoshi 札幌医科大学, 医学部, 教授 (50165180)
TOKINO Takashi 札幌医科大学, 医学部, 教授 (40202197)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 臨床腫瘍学 / エピジェネティクス |
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| Research Abstract |
In the present study, we examined the relationship between Wnt signaling and epigenetic alteration of the secreted frizzled-related protein (SFRP) genes in OSCC. Our results confirm the frequent methylation and silencing of SFRP genes in OSCC, and suggest that their loss of function contributes to activation of Wnt signaling that leads to cell proliferation during oral carcinogenesis.
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