2010 Fiscal Year Final Research Report
The induction of dedifferentiation by hypoxia in OSCC cell lines.
| Project/Area Number |
21792030
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
DHASHI Masaru Showa University, 歯学部, 兼任講師 (40317524)
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| Co-Investigator(Renkei-kenkyūsha) |
TATSUHITO Nagumo 昭和大学, 歯学部, 助教 (70555078)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 低酸素 / 癌幹細胞 / ニッチ |
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| Research Abstract |
Recent data suggest that a rare subpopulation of cancer cells, termed cancer stem cells (CSCs), is capable of initiating, maintaining, and expanding the growth of tumor. Furthermore, these CSCs are considered a major cause of tumor recurrence after conventional therapy due to their resistance against chemo- and radio-therapeutic modalities. Thus, CSCs represent a critical therapeutic target. Recently, a number of studies have demonstrated that hypoxic tumour microenvironment controls tumour stem cells. In this study, we investigated the induction of dedifferentiation by hypoxic condition in OSCC cell lines.
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