2010 Fiscal Year Final Research Report
Establishment of the method for oral tissue construction using gap junctional communication.
| Project/Area Number |
21792054
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
YAMADA Aya Tohoku University, 大学院・歯学研究科, 助教 (40295085)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | エナメル質再生 / 細胞間結合 / Gja1 |
|---|
| Research Abstract |
Gja1 regulates ameloblastin expression in dental epithelium. We have reported that ERK1/2 phosphorylation induced by TGF-β1 regulates expression of ameloblastin via gap junctional intercellular communication.
The results of this study indicated that gap junctional communication regulates intracellular signaling. And these regulatory mechanisms are important to understand the role of gap junctional comunication not only in tooth morphogenesis but also in another organs morphogenesis.
|
