2010 Fiscal Year Final Research Report
Detection of new ion channel in the nerve terminals of the periodontal ligament
| Project/Area Number |
21792064
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
HARADA Fumiko Niigata University, 医歯学系, 特任助教 (00397150)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯学 / 神経科学 / イオンチャネル |
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| Research Abstract |
The acid-sensing ion channel 3 (ASIC3) has been reported to participate in acid sensing, mechanosensation, and nociception. The present study examined the expression of ASIC3 in the lingual periodontal ligament of mouse incisors by immunohistochemistry. Furthermore, the expression of ASIC3 in the trigeminal ganglion-which innervates the periodontal ligament-was investigated at protein and mRNA levels. These findings suggest that ASIC3 functions as a molecule for mechanosensation in the periodontal Ruffini endings.
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