Analysis of mechanism of endothelial hyperplasia caused by P.gingivalis infection

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792066
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Osaka University
• Principal Investigator: NEMOTO Hirotoshi Osaka University, 歯学部附属病院, 医員 (80527226)
• Project Period (FY): 2009 – 2010
• Keywords: 口腔細菌 / 歯周病 / P.gingivalis / 血管内皮 / 肥厚 / S100ファミリータンパク / 平滑筋

Research Abstract

Analysis of human aortic aneurysm specimens by PCR showed that the detection frequency of Porphyromonas gingivalis, a major periodontopathic bacterial species, was approximately 10%. Furthermore, histochemical analysis revealed that the intensity of S100A9 expression was significantly higher in patients harboring oral P.gingivalis than in those who did not. In addition, the proliferative type of smooth muscle cells was prominently identified in patients harboring oral P.gingivalis.

Research Products

• [Journal Article] Characterization of aortic aneurysm of cardiovascular diseases patients with P.gingivalis occurrence. (2011)
  • Author(s): Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Hata H, Toda K, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
  • Journal Title: Oral Dis 17 Pages: 371-378
  • Peer Reviewed
• [Journal Article] Distribution of periodontopathic bacterial species in Japanese children with developmental disabilities. (2009)
  • Author(s): Naka S, Yamana A, Nakano K, Okawa R, Fujita K, Kojima A, Nemoto H, Nomura R, Matsumoto M, Ooshima T.
  • Journal Title: BMC Oral Health 9 Pages: 24
  • Peer Reviewed
• [Journal Article] Detection of serotype k Streptococcus mutans in Thai subjects. (2009)
  • Author(s): Lapirattanakul J, Nakano K, Nomura R, Nemoto H, Kojima A, Senawongse P, Srisatjaluk R, Ooshima T.
  • Journal Title: Oral Microbiol Immunol 24 Pages: 431-433
  • Peer Reviewed
• [Journal Article] Molecular and clinical analyses of the gene encoding collagen-binding adhesin of Streptococcus mutans. (2009)
  • Author(s): Nomura R, Nakano K, Tanigichi N, Lapirattanakul J, Nemoto H, Gronroos L, Alaluusua S, Ooshima T.
  • Journal Title: J Med Microbiol 58 Pages: 469-475
  • Peer Reviewed
• [Journal Article] Detection of oral bacteria in cardiovascular specimens. (2009)
  • Author(s): Nakano K, Nemoto H, Nomura R, Inaba H, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
  • Journal Title: Oral Microbiol Immunol 24 Pages: 64-68
  • Peer Reviewed
• [Journal Article] Molecular analyses of bacterial DNA in extirpated heart valves from infective endocarditis patients. (2009)
  • Author(s): Nomura R, Nakano K, Nemoto H, Mukai T, Hata H, Toda K, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
  • Journal Title: Oral Microbiol Immunol 24 Pages: 43-49
  • Peer Reviewed
• [Presentation] Prevalence of amoxicillin-resistant Streptococci in dental plaque of young Japanese. (2011)
  • Author(s): Nemoto H, Nakano K, Masuda K, Nomura R, Ooshima T.
  • Organizer: 89th IADR meeting
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2011-03-16
• [Presentation] 小児デンタルプラーク中に存在するアモキシシリン耐性口腔細菌種の特定 (2010)
  • Author(s): 根本浩利, 仲野和彦, 野村良太, 大嶋隆
  • Organizer: 平成22年度日本小児歯科学会秋季大会
  • Place of Presentation: 郡山
  • Year and Date: 2010-12-02
• [Presentation] Detection of amoxicillin-resistant streptococcal species in dental plaque specimens. (2010)
  • Author(s): Nemoto H, Nakano K, Nomura R, Wada K, Ooshima T.
  • Organizer: 88th IADR meeting
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 2010-07-14
• [Presentation] 小児プラーク中に存在するアモキシシリン耐性菌の分布に関する検討 (2009)
  • Author(s): 根本浩利, 仲野和彦, 野村良太, 松本道代, 大嶋隆
  • Organizer: 第28回日本小児歯科学会近畿地方会大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-18
• [Presentation] 心臓血管系疾患患者の病変部およびデンタルプラーク検体における口腔細菌種の検出 (2009)
  • Author(s): 根本浩利, 仲野和彦, 野村良太, 大嶋隆
  • Organizer: 第47回日本小児歯科学会大会
  • Place of Presentation: 吹田
  • Year and Date: 2009-05-14