2010 Fiscal Year Final Research Report
The presence of specific oral streptococci and hyperfunction of innate immune responce are causative factors for childhood allergy diseases in oral area.
| Project/Area Number |
21792069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Dental College (2010)
Osaka University (2009) |
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Principal Investigator |
SAKURAI Atsuo Tokyo Dental College, 歯学部, 助教 (90431759)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 小児歯科学 / 口腔レンサ球菌 / 上皮細胞 / 自然免疫 |
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| Research Abstract |
Streptococcus sanguinis is a predominant bacterium in the human oral cavity. Some S. sanguinis strains are considered benetifical because they are reported to attenuate imflamatory responses caused by periodontopathogens. We identified S. sanguinis strain SK36 had an ability to adhere to and invade into human epithelial cells. Pili of S. sanguinis was an important factor to bind to fibronectin, and such binding ability to ECM proteins contribute to such invasion. SK36 enhances the immune responses of host cells such as overexpression of inflammatory cytokines and beta-defensin. A standard S. sanguinis strain ATCC10556 and pili defective mutant of SK36 failed to invade into epithelial cells and to stimulate the immune response. Taken together, our results suggest the possible involvement of pili in the pathogenesis of infective endocarditis, oral allergic diseases, and disorder of immune system.
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[Journal Article] Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation.2011
Author(s)
N.Okahashi, M.Nakata, Y.Terao, R.Isoda, A.Sakurai, T.Sumitomo, M.Yamaguchi, R.K.Kimura, E.Oiki, S.Kawabata, T.Ooshima.
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Journal Title
Microbial Pathogenesis. 50
Pages: 148-154
Peer Reviewed
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[Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.2010
Author(s)
N.Okahashi, N.Masanobu, A.Sakurai, T.Terao, T.Hoshino, M.Yamaguchi, R.Isoda, T.Sumitomo, K.Nakano, S.Kawabata, T.Ooshima.
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Journal Title
Biochemical and Biophysical Research Communications. 391(2)
Pages: 1192-1196
Peer Reviewed
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[Journal Article] Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content.2009
Author(s)
F.Maruyama, M.Kobata, K.Kurokawa, K.Nishida, A.Sakurai, K.Nakano, R.Nomura, S.Kawabata, T.Ooshima, K.Nakai, M.Hattori, S.Hamada, I.Nakagawa.
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Journal Title
BMC genomics. 10(Aug.5)
Pages: 358-378
Peer Reviewed
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