2011 Fiscal Year Final Research Report
Regulation of growth-plate chondrocyte differentiation by self-produced secreted and membrane proteins
| Project/Area Number |
21792086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
HIDAKA Kiyoshi 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10389421)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Masaya 福島県立医科大学, 医学部, 准教授 (20446115)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 軟骨細胞 / 軟骨細胞分化 / 成長軟骨 / 分泌蛋白質 / SST-REX法 |
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| Research Abstract |
This is the study to screen proteins with signal sequence at their N-terminus produced by growth-plate chondrocytes to find key molecules to regulate chondrocyte differentiation by autocrine/ paracrine mechanisms. More than 70 of secreted and membrane proteins were identified by SST-REX method. We focused on secreted protein IGFBP5 and membrane protein FGFR5, and found that these proteins were expressed at specific stage during the differentiation in vivo and in vitro.
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