2010 Fiscal Year Final Research Report
The diagnosis of the risk of periodontitis: searching for the interleukin-6 receptor
| Project/Area Number |
21792114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
KOMATSU Yasutaka Niigata University, 医歯学総合病院, 助教 (40422597)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯周炎 / IL-6 / IL-6レセプター |
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| Research Abstract |
Soluble interleukin-6 receptor (sIL-6R) and soluble gp130 (sgp130) are key molecules in regulation of IL-6 response. Multiple logistic regression analysis revealed significant association between genetic polymorphisms of IL-6R+48892 (A/C) and susceptibility to periodontitis. Moreover, cell surface expression of membrane-bound IL-6R in PBMC and lymphocyte was significantly higher in subjects who carry IL-6R+48892 A allele than that who did not carry. These results suggest that IL-6R gene polymorphisms could act as a risk factor for chronic periodontitis by regulating immunological cell surface expression of IL-6R and sIL-6R levels.
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