2010 Fiscal Year Final Research Report
Development of a sensing system for thrombus formation factors produced by periodontopathic bacterium.
| Project/Area Number |
21792127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KASAI Hironori Kyushu Dental College, 歯学部, 助教 (60398469)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯周病 / 血栓形成 / 微小流路 |
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| Research Abstract |
To investigate the relation between periodontitis and myocardial infarction, we have developed a sensing system for thrombus formation factors produced by periodontopathic bacterium. As a result, we observed increased plaque formation by macrophages in the presence of LPS. In addition, the plaque formation was decreased after infection with Aggregatibacter actinomycetemcomitans. We showed that foam cell formation in macrophages was significantly enhanced by stimulation of LDL.
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