2010 Fiscal Year Final Research Report

Regulatory mechanism of neural stem cell maintenance in the embryonic and adult brain

Research Project

Project/Area Number	21870010
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Developmental biology
Research Institution	The University of Tokyo
Principal Investigator	KAWAGUCHI Daichi The University of Tokyo, 分子細胞生物学研究所, 助教 (70549518)
Research Collaborator	GOTOH Yukiko 東京大学, 分子細胞生物学研究所, 教授 (70252525)
Project Period (FY)	2009 – 2010
Keywords	脳・神経 / 発生・分化 / 神経幹細胞 / 幹細胞ニッチ / Notch
Research Abstract	In the adult mammalian brain, the subventricular zone (SVZ) is the largest neurogenic niche for neural stem cells (NSCs). It is hypothesized that microenvironment of the SVZ may have specific factors that are permissive for the maintenance and differentiation of NSCs. However, the identity of stem cell niche and the regulatory mechanism of NSC maintenance are still largely unknown. In this study, we found that Notch ligand Dll1-expressing cells function as the niche cells for NSC maintenance in the adult SVZ.

(5 results)