2010 Fiscal Year Final Research Report
Analysis of translesion synthesis at replication fork in vitro
| Project/Area Number |
21870023
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
FURUKOHRI Asako Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (90546293)
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| Project Period (FY) |
2009 – 2010
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| Keywords | DNA複製 / DNA修復 / 突然変異 / 大腸菌 |
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| Research Abstract |
The aim of this study is finding a new role of translesion DNA polymerase in a mechanism for chromosomal DNA replication. Using E.coli in vitro DNA replication system, we found that the polymerase switching from replicative polymerase Pol III to translesion polymerase Pol IV was stimulated by the action of Pol IV.
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[Journal Article] Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication.2011
Author(s)
Kundu LR, Seki M, Watanabe N, Murofushi H, Furukohri A, Waga S, Score AJ, Blow JJ, Horikoshi M, Enomoto T, Tada S.
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Journal Title
Biochim Biophys Acta. 1813(6)
Pages: 1129-1136
Peer Reviewed
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[Presentation] Overproduction of Escherichia coli DNA Polymerase DinB(Pol IV) Inhibits Replication Fork Progression and is Lethal.2010
Author(s)
Uchida K, Furukohri A, Shinozaki Y.Mori T, Ogawara D, Kanaya S, Nohmi T, Maki H, Akiyama M
Organizer
The 57th NIBB Conference THE DYNAMIC GENOME
Place of Presentation
Okazaki Conference Center, Okazaki, Aichi, Japan
Year and Date
2010-10-14
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