2010 Fiscal Year Final Research Report
Biomechanical regulation of cell shape, proliferation and cell death
| Project/Area Number |
21870040
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphology/Structure
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
HAYASHI Takashi National Institute of Genetics, 個体遺伝研究系, 助教 (50553765)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 発生 / 形態 / 成長 / 細胞死 |
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| Research Abstract |
The roles of biomechanics on cell shape control, proliferation and cell death were studied using Drosophila melanogaster as the model system. It has been shown that the shape of cells is under the control of surface tension, which is produced by cytoskeletons, by studying the effects of manipulating the function of Rho, Rac or non-muscle Myosin in vivo. An experimental system for studying the roles of biomechanics on proliferation or cell death has also been established.
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