2010 Fiscal Year Final Research Report
Establishment of new strategy for targeting lung cancer stem cells by using bone marrow-derived mesenchymal stem cells
| Project/Area Number |
21890011
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KANEHIRA Masahiko Tohoku University, 大学院・医学系・研究科, 非常勤講師 (90374941)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 肺癌 / 癌幹細胞 / 骨髄由来間葉系幹細胞 |
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| Research Abstract |
Side population in A549 decreased by co-culturing with bone marrow-derived mesenchymal stem cell (BMMSCs). Moreover, expression levels Shh, BMP4 and Muc5AC in A549 were increased. These data suggest that BMMSCs would drive tumor stem cells in A549 toward differentiated. Moreover, production of Fgf10 was promoted in existence of A549, and neutralization of Fgf10 cancelled the SP decreasing effect of BMMSCs.
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