2010 Fiscal Year Final Research Report
adipogenesis and chemical biology
| Project/Area Number |
21890013
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
OKAMURA Masashi Tohoku University, 大学院・医学系・研究科, 助手 (60547397)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 低酸素 / PAI-I / 脂肪細胞分化 |
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| Research Abstract |
Overexpression of PHD1,2,3 and 4 or siRNA-mediated knockdown of PHD1 and 2 did not affect 3T3-L1 adipogenesis. We successfully transferred and set up Phd1^<ff>Phd2^<ff>Phd3^<ff>, Phd2^<ff>, Phd3^<f+>and Phd2^<ff>Rosa26^<+/CreERT2>mice from Connecticut University. By using 7 x HRE artificial promoter, we screened various compounds and founded new compounds equivalent to cobalt.
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[Journal Article] The peroxisome proliferator-activated receptor gamma/ retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.2009
Author(s)
Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa N S, Tanaka T, Sakakibara I, Kitakami J, Ihara S, Hashimoto Y, Hamakubo T, Kodama T, Aburatani H, Sakai J.
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Journal Title
Mol Cell Biol. 29(13)
Pages: 3544-55
Peer Reviewed
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[Journal Article] COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.2009
Author(s)
Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J.
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Journal Title
Proc Natl Acad Sci U S A. 106(14)
Pages: 5819-24
Peer Reviewed
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