Study Design and Statistical Analysis in a Genome-Wide Pharmacogenomics Study

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890035
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Human genetics
• Research Institution: Chiba University
• Principal Investigator: SATO Yasunori Chiba University, 医学部附属病院, 講師 (90536723)
• Project Period (FY): 2009 – 2010
• Keywords: ゲノム / 薬剤反応性 / 統計科学 / 遺伝疫学

Research Abstract

The purpose of this research is to examine problems of study design and analyzing methods for genome-wide pharmacogenomics studies from statistical viewpoints, and then to present new proposals in order to contribute to the development of personalized. In this study, three specific issues were addressed regarding the genome-wide pharmacogenomics studies as follows ; i) Statistical analysis for the association between pharmacokinetics and SNP, ii) Statistical analysis for the association between clinical outcome and SNP, iii) Statistical analysis for PK and SNP-PD modeling. These findings of research were reported in academic journals and meetings.

Research Products

• [Journal Article] Genome-wide association study detected candidate polvmorphisms associated with overall survival (OS) in advanced non-small cell lung cancer treated with carboplatin and paclitaxel. (2011)
  • Author(s): Sato Y, Yamamoto N, Kunitoh H, Ohe Y, Minami H, Laird NM, Katori N, Saito Y, Ohnami S, Sakamoto H, Sawada J, Saijo N, Yoshida T, Tamura T.
  • Journal Title: J Thorac Oncol. 6 Pages: 132-138
  • Peer Reviewed
• [Journal Article] Detection of inappropriate samples in association studies by an IBS-based method considering linkage disequilibrium between genetic markers. (2010)
  • Author(s): Andoh M, Sato Y, Sakamoto H, Yoshida T, Ohtaki M.
  • Journal Title: J Hum Genet. 53 Pages: 436-440
  • Peer Reviewed
• [Journal Article] Bio statistic tools in Pharmacogenomics-advances, challenges, potential. (2010)
  • Author(s): Sato Y, Laird NM, Yoshida T.
  • Journal Title: Cur Pharm Design.
  • Peer Reviewed
• [Journal Article] Genetic Polymorphisms in Folate and Alcohol metabolism and breast cancer risk : A case-control study in Thai women. (2010)
  • Author(s): Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Khuhaprema T, Yoshida T.
  • Journal Title: Breast Cancer Res Treat.
  • Peer Reviewed
• [Journal Article] 個別化医療のための研究デザインと統計解析法 (2010)
  • Author(s): 佐藤泰憲, 長島健悟, 浜田知久馬
  • Journal Title: 臨床薬理 41 Pages: 291-300
  • Peer Reviewed
• [Journal Article] Statistical screening method for genetic. factors influencing susceptibility to common diseases in a two-stage genome-wide association study. (2009)
  • Author(s): Sato Y, Laird N, Suganami H. Hamata C, Niki N, Yoshimura I, Yoshida T.
  • Journal Title: Stat Appl Genet Mol Biol.
  • Peer Reviewed
• [Presentation] Studentized modified maximum contrast method for unequal sample sizes in pharmacogenomics Studies. (2010)
  • Author(s): Nagashima K, Sato Y. Hamada C.
  • Organizer: International Biometric Society.
  • Place of Presentation: Florianopolis, Brazil.
  • Year and Date: 2010-12-10
• [Presentation] Genome-wide association scan detected candidate polymorphisms associated with overall survival (OS) in advanced non-small cell lung cancer (NSCLC) treated with carboplatin (CBDCA) and paclitaxel (PTX). (2009)
  • Author(s): Sato Y, Yamamoto N, Tamura T, Kunitoh H, Ohe Y, Katori N, Sawada J, Sakamoto H, Saijo N, Yoshida T.
  • Organizer: 第45回米国臨床腫瘍学会
  • Place of Presentation: 米国・オーランド
  • Year and Date: 20090530-20090601
• [Presentation] Genome-wide association scan detected candidate polymorphisms associated with overall survival in stage IV pancreatic adenocarcinoma patients receiving gemcitabine monotherapy. (2009)
  • Author(s): Uenol H, Okusakal T, Furuse J, Ishii H, Saijo N, Saito Y, Sawada J, Sakamoto H, Yoshida T, Sato Y.
  • Organizer: 第45回米国臨床腫瘍学会
  • Place of Presentation: 米国・オーランド
  • Year and Date: 20090530-20090601