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2010 Fiscal Year Final Research Report

Epigenetic mechanisms of antipsychotic drugs in glial cells

Research Project

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Project/Area Number 21890091
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionUniversity of Yamanashi

Principal Investigator

MIYAKE Kunio  University of Yamanashi, 医学工学総合研究部, 助教 (60550712)

Project Period (FY) 2008 – 2010
Keywords精神疾患 / 抗精神病薬 / エピジェネティクス / グリア細胞
Research Abstract

It has been suggested that glial cells are involved in pathological condition of mental disorder. However, the details of mechanism are still unknown. We showed here that treatment with an antipsychotic drug influences glial cell proliferation and changes the pattern of histone acetylation by coadministration of sodium butylate and inhibits the LPS-induced inflammatory response. These results can expect to lead to the development of new antipsychotic drugs as a target for glial cells.

  • Research Products

    (7 results)

All 2011 2010 Other

All Journal Article (1 results) Presentation (2 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Novel etiological and therapeutic strategies for neurodiseases : epigenetic understanding of gene-environment interactions.2010

    • Author(s)
      Kubota T, Miyake K, Hirasawa T, Nagai K, Koide T.
    • Journal Title

      J Pharmacol Sci 113

      Pages: 3-8

  • [Presentation] レット症候群責任蛋白質MeCP2の新規標的シナプス関連分子の同定2010

    • Author(s)
      三宅邦夫
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-08
  • [Presentation] レット症候群責任蛋白質MeCP2の新規標的遺伝子の探索2010

    • Author(s)
      三宅邦夫
    • Organizer
      第4回日本エピジェネティクス研究会
    • Place of Presentation
      米子市文化ホール
    • Year and Date
      2010-05-28
  • [Book] 精神疾患のエピジェネティクス:メチル化CpG結合蛋白(MeCP2)研究の最近の動向2011

    • Author(s)
      三宅邦夫、久保田健夫
    • Total Pages
      6-11
    • Publisher
      先端医学社
  • [Book] Epigenetics in autism and other neurodevelopmental diseases.Molecular Mechanism of Neurodegenerative diseases2011

    • Author(s)
      Miyake K, Hirasawa T, Koide T, Kubota T
    • Publisher
      Landes Bioscince/Springer(in press)
  • [Book] エピジェネティクス.増刊号:遺伝子診療学-遺伝子診断の進歩とゲノム治療の展望2010

    • Author(s)
      三宅邦夫、久保田健夫
    • Total Pages
      87-92
    • Publisher
      日本臨床
  • [Remarks] ホームページ等

    • URL

      http://www.epigenetmed.com/

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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