The effect of hypothermia on the inner and outer hair cell damages due to cochlear ischemia.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890173
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Ehime University
• Principal Investigator: HAKUBA Nobuhiro Ehime University, 医学部附属病院, 講師 (70304623)
• Project Period (FY): 2009 – 2010
• Keywords: 虚血性内耳障害 / 内・外有毛細胞 / 低体温

Research Abstract

The effect of post-ischemic hypothermia on the inner ear had not been clarified. We investigated whether hypothermia after transient ischemia could prevent the inner and outer hair cell damages and its therapeutic time window. The protective effect was greater when the hypothermia was induced earlier and had a longer duration.

Research Products

• [Journal Article] Ear-pick injury as a traumatic ossicular damage in Japan. (2010)
  • Author(s): Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi Hiratsuka Y, Kumabe Y, Konishi M, Okanoue Y, Hiwatashi N, Wada T
  • Journal Title: Eur Arch Oto-Rhino-L 267(7) Pages: 1035-1039
  • Peer Reviewed
• [Journal Article] Ear-pick injury as a traumatic ossicular damage in Japan. (2010)
  • Author(s): Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi M, Okanoue Y, Hiwatashi N, Wada T
  • Journal Title: Eur Arch Oto-Rhino-L 267(7) Pages: 1035-1039
  • Peer Reviewed
• [Journal Article] Prednisolone prevents transient ischemia-induced cochlear damage in gerbils. (2009)
  • Author(s): Maetani T, Hyodo J, Takeda S, Hakuba N, Kiyofumi G.
  • Journal Title: Acta Otolaryngol Suppl. 562 Pages: 24-27
  • Peer Reviewed
• [Journal Article] Measurement of DPOAE after ischemia/reperfusion injury of the cochlea in gerbils. (2009)
  • Author(s): Watanabe F, Hakuba N, Gyo K
  • Journal Title: Neurosci Lett. 267 Pages: 135-138
  • Peer Reviewed
• [Journal Article] Ischemic tolerance in the cochlea. (2009)
  • Author(s): Takeda S, Hata R, Cao F, Yoshida T, Hakuba N, Hato N, Gyo K.
  • Journal Title: Neurosci Lett. 262 Pages: 263-266
  • Peer Reviewed
• [Journal Article] Glutamate agonist causes irreversible degeneration of inner hair cells. (2009)
  • Author(s): Hyodo J, Hakuba N, Hato N, Takeda Shoichirou, Okada, Omotehara, Gyo K.
  • Journal Title: Neuroreport. 23 Pages: 1255-1259
  • Peer Reviewed
• [Presentation] Glutamate agonist causes irreversible degeneration of inner hair cells (2010)
  • Author(s): Hakuba N, Gyo K
  • Organizer: Inner Ear Biology(一般講演)
  • Place of Presentation: チェコ
  • Year and Date: 20100000
• [Presentation] 穿孔性中耳炎に対する鼓膜再生治療 (2010)
  • Author(s): 白馬伸洋
  • Organizer: 喜多八幡浜耳鼻咽喉科医会講演会(教育講演)
  • Place of Presentation: 愛媛
  • Year and Date: 20100000
• [Presentation] 穿孔性中耳炎に対する鼓膜再生治療 (2010)
  • Author(s): 白馬伸洋
  • Organizer: 岡山Translation研究会(特別講演)
  • Place of Presentation: 岡山
  • Year and Date: 20100000
• [Presentation] 穿孔性中耳炎に対する鼓膜再生治療 (2010)
  • Author(s): 白馬伸洋
  • Organizer: 東予耳鼻科会(特別講演)
  • Place of Presentation: 愛媛
  • Year and Date: 20100000
• [Presentation] 鼓膜再生による新しい穿孔性中耳の治療法 (2010)
  • Author(s): 白馬伸洋
  • Organizer: 信州耳鼻咽喉科臨床問題懇話会(招待講演)
  • Place of Presentation: 長野
  • Year and Date: 20100000
• [Presentation] 耳鼻咽喉科の再生治療 (2009)
  • Author(s): 白馬伸洋
  • Organizer: 愛媛県医師会生涯研究(特別講演)
  • Place of Presentation: 愛媛
  • Year and Date: 20090000
• [Presentation] MRSA中耳炎に対する治療 (2009)
  • Author(s): 白馬伸洋
  • Organizer: 栃木下野耳鼻咽喉科アレルギー感染症研究会(招待講演)
  • Place of Presentation: 栃木
  • Year and Date: 20090000
• [Presentation] 虚血性内耳病変の発症機序と臨床 (2009)
  • Author(s): 白馬伸洋
  • Organizer: 東大阪ORL研究会(特別講演)
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Presentation] 新しい鼓膜穿孔閉鎖法 (2009)
  • Author(s): 白馬伸洋
  • Organizer: 第5回明石耳鼻咽喉科学術講演会(特別講演)
  • Place of Presentation: 兵庫
  • Year and Date: 20090000
• [Book] アテロコラーゲン/シリコン膜とヒト線維芽細胞増殖因子(bFGF)製剤を用いた鼓膜穿孔閉鎖術(遺伝子医学MOOK再生遺伝子治療 患者までとどいている再生誘導治療,第1版)(田畑康彦編) (2009)
  • Author(s): 白馬伸洋
  • Total Pages: 139-143
  • Publisher: 大阪:メディカルドゥ
• [Remarks] ホームページ等