• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

To clarify the molecular mechanism of novel therapeutic agent which suppresses bone resorption through inhibits noncanonical Wnt signaling.

Research Project

  • PDF
Project/Area Number 21890261
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionJikei University School of Medicine

Principal Investigator

MAEDA Kazuhiro  Jikei University School of Medicine, 医学部, 助教 (50548849)

Project Period (FY) 2009 – 2010
Keywords破骨細胞 / Wnt
Research Abstract

We have previously reported that noncanonical Wnt signaling enhanced osteoclastogenesis. To clarify the role of noncanonical Wnt signaling in osteoclastogenesis, we generated osteoclast precursor-specific Ror2, one of the noncanonical Wnt receptor,-deficient mice. These mice exhibited impaired osteoclastogenesis due to suppression of RANK expression in osteoclast precursors, indicating that noncanonical Wnt signaling enhances osteoclastogenesis through RANK expression.

  • Research Products

    (5 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Regulatory Mechanism of Osteoclastogenesis by Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Wnt Signals.2011

    • Author(s)
      N.Takahashi, K.Maeda, A.Ishihara, S.Uehara, Y.Kobayashi
    • Journal Title

      Front Biosci. 16

      Pages: 21-30

    • Peer Reviewed
  • [Journal Article] Vocabulary『Wnt5a』2009

    • Author(s)
      前田和洋
    • Journal Title

      整形外科 60

      Pages: 1100

  • [Presentation] Wnt5aによる破骨細胞の分化促進効果2010

    • Author(s)
      小林泰浩、前田和洋、上原俊介、高田伊知郎、加藤茂明、丸毛啓史、宇田川信之、高橋直之
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
  • [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions.2010

    • Author(s)
      Y.Kobayashi, K.Maeda, A.Ishihara, S.Uehara, Takada, S.Kato, M.Nishita, Y.Minami, K.Marumo, N.Udagawa, N.Takahashi
    • Organizer
      第3回国際骨免疫学会議
    • Place of Presentation
      Santorini, Greece
    • Year and Date
      2010-06-22
  • [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions.2009

    • Author(s)
      Y.Kobayashi, K.Maeda, A.Ishihara, I.Takada, S.Kato, M.Nishita, Y.Minami, K.Marumo, N.Udagawa, N.Takahashi
    • Organizer
      The 26^<th> Naito conference on osteobiology
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      2009-11-04

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi