2010 Fiscal Year Final Research Report

Investigation of pathological effects of periodontopathic bacteria on endothelial cells forming capillary-like tube networks

Research Project

Project/Area Number	21890275
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Pathobiological dentistry/Dental radiology
Research Institution	Asahi University
Principal Investigator	INOMATA Megumi Asahi University, 歯学部, 助教 (40553798)
Project Period (FY)	2009 – 2010
Keywords	歯周病原細菌 / Porphyromonas gingivalis / LPS / 歯周組織由来細胞 / 血管内皮細胞 / LL-37
Research Abstract	Recently, it has been reported that proinflammatory responses of host cells to periodontopathic bacteria Porphyromonas gingivalis (Pg) affect not only periodontal functions but also general health. This study therefore investigated the responses of host cells to Pg. Intriguingly, dead Pg cells, but not live cells, had cell-stimulating activity. In addition, Pg components, including LPS, lipid A, and fimbriae also activated cell responses. These results suggested that live Pg cells can evade from host recognition and invade into host cells to conceal themselves. Furthermore, live Pg cells killed by several in-host factors may activate proinflammatory responses of host cells.

(2 results)