A New Strategy for Substitution Reactions of Alkyl C-H Bonds Based on Parallel Catalysis

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H01937
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Kyoto Institute of Technology (2022-2023); Kyoto University (2021)
• Principal Investigator: Ohmura Toshimichi 京都工芸繊維大学, 分子化学系, 教授 (00378803)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 合成化学 / 触媒的分子変換 / 炭素－水素結合活性化 / 炭素－炭素結合形成

Outline of Final Research Achievements

A new strategy for achieving substitution reactions of the C-H bonds on alkyl groups based on 'parallel catalysis', in which the 'dehydrogenation catalytic cycle' and the 'C-H addition catalytic cycle' work in parallel, was established and a catalytic carbon-carbon bond formation reaction utilizing inert alkyl groups was developed. The strategy was also applied to catalytic carbon-heteroatom bond formation reactions through substitution of the C-H bonds of inert alkyl groups. These results are expected to contribute to the production of functional organic molecules with low environmental impact and energy conservation.

Free Research Field

有機金属化学、有機合成化学

Academic Significance and Societal Importance of the Research Achievements

低環境負荷・省エネルギーでの物質創成に対する社会的要請の高まりに伴って、ハロゲン化アルキルやアルケンの変換に頼る従来の多段階分子創出は時代遅れになりつつある。本研究で確立したパラレル触媒作用に基づく新戦略により、原材料のアルキル化合物から直接機能性有機分子を得る革新的分子変換に道が拓かれた。廃棄物の低減とエネルギー消費の抑制に寄与する新しい分子創出概念の確立は、学術的・社会的に意義深いと考えられる。