Pioneering Separation and Measurement Technologies Based on Zinc Oxide Nanowires

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H01968
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 34020:Analytical chemistry-related
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: Umemura Tomonari 東京薬科大学, 生命科学部, 教授 (10312901)
• Co-Investigator(Kenkyū-buntansha): 安井 隆雄 名古屋大学, 工学研究科, 准教授 (00630584) ; 中嶋 秀 東京都立大学, 都市環境科学研究科, 准教授 (10432858) ; 手嶋 紀雄 愛知工業大学, 工学部, 教授 (30292501)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ナノワイヤ / レーザー脱離イオン化質量分析 / 超薄層クロマトグラフィー / 酸化亜鉛 / SALDI / UTLC

Outline of Final Research Achievements

In order to establish a mass spectrometry method with excellent robustness for practical use in clinical and other settings, the development of highly functionalized target plates for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) was investigated. By modifying a glass slide surface with metal and metal oxide nanostructures, the modified glass slide with electrical conductivity can not only be utilized as a target plate, but also intermolecular separation was successfully achieved on this plate using the gaps between the structures and their surface chemical properties. Furthermore, photothermal conversion properties of the metal-based nanostructures enabled direct laser heating (desorption) without spraying organic matrix reagents, and a series of chemical operations from separation and purification to mass spectrometry could be successfully and efficiently performed.

Free Research Field

分析化学

Academic Significance and Societal Importance of the Research Achievements

科学の進歩には革新的な分析法・分析技術の開発が不可欠である。本研究は、酸化亜鉛ナノワイヤの物理的な特性や化学的な特性を駆使して、分離分析と質量分析を1枚のプレート上で融合させようという提案であり、実用性と発展性を兼ね備えたポテンシャルの高い分析法として学術的にも実践的にも意義は大きいと思われる。