Investigation of the cancer-resistance mechanisms in the longest-lived rodent, the naked mole-rat.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H02392
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 42040:Laboratory animal science-related
• Research Institution: Kumamoto University
• Principal Investigator: Miura Kyoko 熊本大学, 大学院生命科学研究部(医), 教授 (80583062)
• Co-Investigator(Kenkyū-buntansha): 坊農 秀雅 広島大学, 統合生命科学研究科(理), 教授 (20364789) ; 坂井 祐介 国立感染症研究所, 感染病理部, 主任研究官 (60615722)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ハダカデバネズミ

Outline of Final Research Achievements

We showed that the naked mole-rat (NMR) exhibits significantly attenuated inflammatory responses that may play a role in suppressing cancer promotion and various age-related diseases in this species. One possible mechanism is the species-specific loss of the ability to induce necroptosis and a death-inducing mechanism in senescent cells. On the other hand, when cells were transformed by transducing oncogenes in the NMR body, tumors were formed. This suggests that there may be NMR-specific defense mechanisms that suppress or eliminate abnormal cell proliferation in the body before reaching transformation.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

本研究が進展することで、ヒトを含む哺乳類における発がんおよびそのメカニズムの理解、また革新的な発がん予防方法につながることが期待される。