2023 Fiscal Year Final Research Report
Novel anti-sulfated glycan antibodies for ovarian cancer pathology diagnosis and photoimmunotherapy
| Project/Area Number |
21H02702
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
赤間 智也 関西医科大学, 医学部, 准教授 (10548788)
長屋 匡信 信州大学, 学術研究院医学系(医学部附属病院), 准教授 (00718033)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 卵巣癌 |
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| Outline of Final Research Achievements |
We generated a novel anti-sulfated carbohydrate antibody, 297-11A, which recognizes galactose-sulfated N-acetyllactosamine structures, and performed clinicopathological analysis of ovarian cancer histopathological specimens. The results showed that 297-11A-positive cases were frequently observed in serous carcinomas, and that it was also expressed in normal fallopian tube epithelial secretory cells, which are considered to be the origin of such carcinomas. In addition, we found that progression-free survival was significantly shorter in 297-11A-sulfated glycosylation-positive ovarian cancer patients than in negative patients.
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| Free Research Field |
糖鎖病理学
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| Academic Significance and Societal Importance of the Research Achievements |
卵巣漿液性癌は卵管上皮を構成する分泌細胞の過剰増殖を引き金に発生すると考えられているが，漿液性癌細胞に加えて，この分泌細胞も297-11A抗体で陽性に染色されるという今回の結果は，この考えをさらに支持するものである。また，297-11A陽性の患者は陰性の患者よりも無増悪生存期間が有意に短いことから，卵巣癌治療における予後予測や，新規治療開発の標的として有望であると考えられる。
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