Comprehensive association study between Complement C4 and schizophrenia

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H02854
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Nagoya University (2023); Fujita Health University (2021-2022)
• Principal Investigator: Ikeda Masashi 名古屋大学, 医学系研究科, 教授 (60424933)
• Co-Investigator(Kenkyū-buntansha): 國井 泰人 東北大学, 災害科学国際研究所, 准教授 (00511651) ; 寺尾 知可史 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (60610459)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 統合失調症 / C4

Outline of Final Research Achievements

Genome-Wide Association Studies (GWAS) of schizophrenia have highlighted the Major Histocompatibility Complex (MHC) region as candidate region, with complement component 4 (C4) being identified as a potential susceptibility gene. In this study, we utilized Japanese schizophrenia GWAS data to perform C4 imputation and examined the associations. Our findings revealed that, in contrast to previously reported data from Caucasian populations, a different haplotype was associated with schizophrenia. These results suggest the possibility of ethnic differences and indicate that further research could lead to a more precise identification of susceptibility genes

Free Research Field

精神医学

Academic Significance and Societal Importance of the Research Achievements

MHC領域と精神疾患の関連は、民族によって異なっている。例えば白人では統合失調症が最も有意である一方、日本人をはじめとした東アジアサンプルでは統合失調症よりも双極性障害で関連性が強いと考えられている。したがって、統合失調症ー双極性障害という疾患の違い、遺伝的民族差を考え合わせると、それぞれの文化での診断傾向などを同定できる可能性があり、臨床精神医学的にも進展が望まれる。