2023 Fiscal Year Final Research Report
Development of PET probes for elucidation of orexin systems
| Project/Area Number |
21H02869
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 52040:Radiological sciences-related
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | オレキシン / グレリン / PET / イメージング |
|---|
| Outline of Final Research Achievements |
In this study, we developed novel PET probes targeting OX1R, OX2R, and GHSR in the brain.
In the development of OX1R targeting PET probes, further modifications for improvement of the pharmacokinetics are needed, but the [18F]PBC-2 has potential for the development of useful PET probes targeting OX1R in the brain.
In the development of GHSR targeting PET probes, although further improvement of the pharmacokinetics is needed, the diaminopyrimidine scaffold, the backbone of [18F]BPP-2, has potential for the development of useful GHSR-targeting PET probes.
|
| Free Research Field |
放射性医薬品学
|
| Academic Significance and Societal Importance of the Research Achievements |
生体内におけるオレキシン系の可視化は精神疾患や睡眠障害などの病態解明，治療薬開発につながり，さらには，その下流に位置する報酬系に関連する神経伝達物質との関連性を明らかにすることで，精神構造の解明の一端を担うことができると考えられる．さらにオレキシン系の解明のみならず，様々な疾患への予防診断を含めた新たな診断基準の発見や新規治療薬開発の進展へ寄与し得ることも期待される．
本研究で得られた成果は、これらへの足がかりになるものと考えられる．
|
