Understanding the Ahr signal for the maintainance of intestinal epithelial cells

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H02905
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Keio University
• Principal Investigator: Ogata Haruhiko 慶應義塾大学, 医学部(信濃町), 教授 (30177117)
• Co-Investigator(Kenkyū-buntansha): 筋野 智久 慶應義塾大学, 医学部(信濃町), 講師 (40464862) ; 細江 直樹 慶應義塾大学, 医学部(信濃町), 准教授 (90317131)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 潰瘍性大腸炎

Outline of Final Research Achievements

Inflammatory bowel disease is characterized by destruction of the intestinal epithelium, and previous studies have revealed that immune regulatory mechanisms mediated by Tregs are important for intestinal epithelial protection. While the molecular mechanisms have been elucidated, the localization and dynamics of Tregs in the gastrointestinal tract have remained unclear for many years, and the mechanism by which Ahr signaling regenerates the intestinal epithelium via Tregs, which are inflammatory suppressor cells, has been elucidated. We have also developed an efficient endoscopic system by using machine learning in endoscopic examinations for inflammatory bowel disease.

Free Research Field

内視鏡学

Academic Significance and Societal Importance of the Research Achievements

これまで明らかでなかったAhr含有物質が腸管のホメオスタシス維持に重要であるというエビデンスに対して、本研究を通じて炎症性腸疾患モデルを抑制することで、その詳細なメカニズムを明らかとした。さらに１細胞の腸管内における局在解析を確立した。