2023 Fiscal Year Final Research Report
Artificial regulation of cutaneous resident memory T cells and their application to skin disease prevention
| Project/Area Number |
21H02940
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小川 陽一 山梨大学, 大学院総合研究部, 講師 (20377542)
岡本 崇 山梨大学, 大学院総合研究部, 講師 (30402043)
三井 広 山梨大学, 大学院総合研究部, 講師 (60372504)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | resident memory T細胞 / 抗原提示細胞 |
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| Outline of Final Research Achievements |
The mechanisms underlying the development, maintenance, and proliferation of antigen-specific resident memory T cells (TRMs) in peripheral tissues have not been elucidated. We have shown that dermal dendritic cells are strongly involved in the development, maintenance, and proliferation of antigen-specific “cutaneous” TRMs, and that epidermal Langerhans cells and dermal mast cells are also partially involved. OX40 signaling between antigen-presenting cells and T cells is partially involved in the development, maintenance, and proliferation of these antigen-specific TRMs.
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| Free Research Field |
皮膚免疫
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| Academic Significance and Societal Importance of the Research Achievements |
抗原特異的resident memory T細胞 (TRM)は生体防御の観点において有益であるが、一方で過剰な免疫反応は有害でもある。本研究では皮膚の抗原特異的TRMの発生、維持、増殖に真皮や表皮に存在する様々な抗原提示細胞が異なる割合で関与することを明らかとし、その中でOX40シグナルが重要であることを見出した。このことはOX40シグナルを人為的に増強あるいは阻害することで抗原特異的TRMの数や機能を制御できることを示唆する。
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