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2023 Fiscal Year Annual Research Report

難治性卵巣がんにおける細胞外小胞機能解析と臨床応用基盤創生

Research Project

Project/Area Number 21H03075
Research InstitutionNagoya University

Principal Investigator

横井 暁  名古屋大学, 医学部附属病院, 病院講師 (30737135)

Co-Investigator(Kenkyū-buntansha) 梶山 広明  名古屋大学, 医学系研究科, 教授 (00345886)
山本 雄介  国立研究開発法人国立がん研究センター, 研究所, ユニット長 (60768117)
吉田 康将  名古屋大学, 医学系研究科, 特任助教 (90885550)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords卵巣がん / がん微小環境 / エクソソーム / マイクロRNA / 細胞外小胞
Outline of Annual Research Achievements

本研究は、卵巣がんにおけるエクソソームを始めとした細胞外小胞(Extracellular Vesicle: EV)を対象とし、EVが有する未だ明らかにされていない腫瘍生物学的意義を明らかにし、臨床応用へ向けた基盤となる知見を得ることを目的とする。あらゆる生細胞が恒常的に放出するEVは、細胞間情報伝達手段として注目されている。今後臨床応用へ向けたトランスレーショナル研究がさらに加速することが予想される一方で、EV研究はその定義や取扱いが未だ議論の的になるほど発展途上である。未だ臨床的問題点が多く残る難治性卵巣がんに於けるEVの機能解明は極めて重要と考えられる。本研究では、①卵巣がん悪性化に関わるEVの機能解析 ②個別化医療を実現するEVバイオマーカーの創出 ③EVによる難治進行性卵巣がんの新規治療開発 の、3点を軸に研究を展開し、卵巣がん患者予後の改善に繋がる成果を得ることを目的として展開する。現在も複数のプロジェクトが進行中である。本年は17論文報告を行っており、中でもIdentifying high-grade serous ovarian carcinoma-specific extracellular vesicles by polyketone-coated nanowiresSci Adv. 2023 Jul 7;9(27):eade6958. Yokoi A, et al.およびSpatial exosome analysis using cellulose nanofiber sheets reveals the location heterogeneity of extracellular vesiclesNat Commun. 2023 Nov 8;14(1):6915. Yokoi A et al.,は本研究目的①-③に対する核となる研究成果であった。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

  • Research Products

    (22 results)

All 2024 2023

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Open Access: 6 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results)

  • [Journal Article] Serum miRNA as a predictive biomarker for ovarian reserve after endometrioma-cystectomy2024

    • Author(s)
      Yabuki Atsushi、Muraoka Ayako、Osuka Satoko、Yokoi Akira、Yoshida Kosuke、Kitagawa Masami、Bayasura、Sonehara Reina、Miyake Natsuki、Nakanishi Natsuki、Nakamura Tomoko、Iwase Akira、Kajiyama Hiroaki
    • Journal Title

      Reproductive Biology

      Volume: 24 Pages: 100821~100821

    • DOI

      10.1016/j.repbio.2023.100821

    • Peer Reviewed
  • [Journal Article] Emerging bacterial factors for understanding pathogenesis of endometriosis2024

    • Author(s)
      Muraoka Ayako、Yokoi Akira、Kajiyama Hiroaki
    • Journal Title

      iScience

      Volume: 27 Pages: 108739~108739

    • DOI

      10.1016/j.isci.2023.108739

    • Peer Reviewed / Open Access
  • [Journal Article] Downregulation of miR10b-5p facilitates the proliferation of uterine leiomyosarcoma cells: A microRNA sequencing based approach2023

    • Author(s)
      Yoshida Kosuke、Yokoi Akira、Kitagawa Masami、Sugiyama Mai、Yamamoto Tomofumi、Nakayama Jun、Yoshida Hiroshi、Kato Tomoyasu、Kajiyama Hiroaki、Yamamoto Yusuke
    • Journal Title

      Oncology Reports

      Volume: 49 Pages: -

    • DOI

      10.3892/or.2023.8523

    • Peer Reviewed / Open Access
  • [Journal Article] DDIT4 Facilitates Lymph Node Metastasis via the Activation of NF-κB Pathway and Epithelial-Mesenchymal Transition2023

    • Author(s)
      Lin Xinxin、Yoshikawa Nobuhisa、Liu Wenting、Matsukawa Tetsuya、Nakamura Kae、Yoshihara Masato、Koya Yoshihiro、Sugiyama Mai、Tamauchi Satoshi、Ikeda Yoshiki、Yokoi Akira、Shimizu Yusuke、Kajiyama Hiroaki
    • Journal Title

      Reproductive Sciences

      Volume: 30 Pages: 2829~2841

    • DOI

      10.1007/s43032-023-01230-y

    • Peer Reviewed
  • [Journal Article] The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation2023

    • Author(s)
      Asano-Inami Eri、Yokoi Akira、Sugiyama Mai、Hyodo Toshinori、Hamaguchi Tomonari、Kajiyama Hiroaki
    • Journal Title

      Communications Biology

      Volume: 6 Pages: -

    • DOI

      10.1038/s42003-023-04754-w

    • Peer Reviewed / Open Access
  • [Journal Article] The prognostic significance of DDIT4 in endometrial cancer2023

    • Author(s)
      Yoshikawa Nobuhisa、Yoshida Kosuke、Liu Wenting、Matsukawa Tetsuya、Hattori Satomi、Yoshihara Masato、Tamauchi Satoshi、Ikeda Yoshiki、Yokoi Akira、Shimizu Yusuke、Niimi Kaoru、Kajiyama Hiroaki
    • Journal Title

      Cancer Biomarkers

      Volume: 37 Pages: 217~225

    • DOI

      10.3233/CBM-220368

    • Peer Reviewed
  • [Journal Article] Downregulating vaccinia-related kinase 1 by luteolin suppresses ovarian cancer cell proliferation by activating the p53 signaling pathway2023

    • Author(s)
      Chang Xuboya、Tamauchi Satoshi、Yoshida Kosuke、Yoshihara Masato、Yokoi Akira、Shimizu Yusuke、Ikeda Yoshiki、Yoshikawa Nobuhisa、Kiyono Tohru、Yamamoto Yusuke、Kajiyama Hiroaki
    • Journal Title

      Gynecologic Oncology

      Volume: 173 Pages: 31~40

    • DOI

      10.1016/j.ygyno.2023.04.003

    • Peer Reviewed
  • [Journal Article] Identifying high-grade serous ovarian carcinoma specific extracellular vesicles by polyketone-coated nanowires2023

    • Author(s)
      Yokoi Akira、Ukai Mayu、Yasui Takao、Inokuma Yasuhide、Hyeon-Deuk Kim、Matsuzaki Juntaro、Yoshida Kosuke、Kitagawa Masami、Chattrairat Kunanon、Iida Mikiko、Shimada Taisuke、Manabe Yumehiro、Chang I-Ya、Asano-Inami Eri、Koya Yoshihiro、Nawa Akihiro、Nakamura Kae、Kiyono Tohru、Kato Tomoyasu、Hirakawa Akihiko et al.
    • Journal Title

      Science Advances

      Volume: 9 Pages: -

    • DOI

      10.1126/sciadv.ade6958

    • Peer Reviewed / Open Access
  • [Journal Article] The sarcopenia index measured using the lumbar paraspinal muscle is associated with prognosis in endometrial cancer2023

    • Author(s)
      Uno Kaname、Yoshikawa Nobuhisa、Kitami Kazuhisa、Mori Sho、Shibata Takahiro、Iyoshi Shohei、Fujimoto Hiroki、Mogi Kazumasa、Yoshihara Masato、Tamauchi Satoshi、Ikeda Yoshiki、Yokoi Akira、Kato Kazuyoshi、Hoshiba Tsutomu、Oguchi Hidenori、Kajiyama Hiroaki
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 53 Pages: 942~949

    • DOI

      10.1093/jjco/hyad086

    • Peer Reviewed
  • [Journal Article] Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles2023

    • Author(s)
      Iitani Yukako、Miki Rika、Imai Kenji、Fuma Kazuya、Ushida Takafumi、Tano Sho、Yoshida Kosuke、Yokoi Akira、Kajiyama Hiroaki、Kotani Tomomi
    • Journal Title

      Pediatric Research

      Volume: 95 Pages: 167~173

    • DOI

      10.1038/s41390-023-02825-6

    • Peer Reviewed
  • [Journal Article] Small Extracellular Vesicles from adipose-derived stem cells suppress cell proliferation by delivering the let-7 family of microRNAs in ovarian cancer2023

    • Author(s)
      Suzuki Hironori、Yokoi Akira、Uno Kaname、Yoshida Kosuke、Kitagawa Masami、Asano-Inami Eri、Matsuo Seiko、Nagao Yukari、Suzuki Kazuhiro、Nakamura Kae、Yoshihara Masato、Tamauchi Satoshi、Shimizu Yusuke、Ikeda Yoshiki、Yoshikawa Nobuhisa、Kajiyama Hiroaki、Yamamoto Yusuke
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 680 Pages: 211~219

    • DOI

      10.1016/j.bbrc.2023.09.022

    • Peer Reviewed / Open Access
  • [Journal Article] Mean platelet volume as a potential biomarker for survival outcomes in ovarian clear cell carcinoma2023

    • Author(s)
      Yoshikawa Nobuhisa、Matsukawa Tetsuya、Hattori Satomi、Iyoshi Shohei、Yoshida Kosuke、Yoshihara Masato、Tamauchi Satoshi、Shimizu Yusuke、Ikeda Yoshiki、Yokoi Akira、Niimi Kaoru、Kawai Michiyasu、Kajiyama Hiroaki
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 28 Pages: 1680~1689

    • DOI

      10.1007/s10147-023-02417-8

    • Peer Reviewed
  • [Journal Article] 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins2023

    • Author(s)
      Mogi Kazumasa、Koya Yoshihiro、Yoshihara Masato、Sugiyama Mai、Miki Rika、Miyamoto Emiri、Fujimoto Hiroki、Kitami Kazuhisa、Iyoshi Shohei、Tano Sho、Uno Kaname、Tamauchi Satoshi、Yokoi Akira、Shimizu Yusuke、Ikeda Yoshiki、Yoshikawa Nobuhisa、Niimi Kaoru、Yamakita Yoshihiko、Tomita Hiroyuki、et al.
    • Journal Title

      Scientific Reports

      Volume: 13 Pages: -

    • DOI

      10.1038/s41598-023-44365-3

    • Peer Reviewed
  • [Journal Article] An update of oncologic and obstetric outcomes of radical trachelectomy for early‐stage cervical cancer: The need for further minimally invasive treatment2023

    • Author(s)
      Tamauchi Satoshi、Iyoshi Shohei、Yoshihara Masato、Yoshida Kosuke、Ikeda Yoshiki、Shimizu Yusuke、Yokoi Akira、Niimi Kaoru、Yoshikawa Nobuhisa、Kajiyama Hiroaki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 50 Pages: 175~181

    • DOI

      10.1111/jog.15824

    • Peer Reviewed
  • [Journal Article] Spatial exosome analysis using cellulose nanofiber sheets reveals the location heterogeneity of extracellular vesicles2023

    • Author(s)
      Yokoi Akira、Yoshida Kosuke、Koga Hirotaka、Kitagawa Masami、Nagao Yukari、Iida Mikiko、Kawaguchi Shota、Zhang Min、Nakayama Jun、Yamamoto Yusuke、Baba Yoshinobu、Kajiyama Hiroaki、Yasui Takao
    • Journal Title

      Nature Communications

      Volume: 14 Pages: -

    • DOI

      10.1038/s41467-023-42593-9

    • Peer Reviewed / Open Access
  • [Journal Article] Effect of radical trachelectomy on ovarian reserve: A single‐institute prospective study2023

    • Author(s)
      Nakagawa Atsushi、Tamauchi Satoshi、Sato Mamiko、Yoshihara Masato、Yokoi Akira、Shimizu Yusuke、Ikeda Yoshiki、Yoshikawa Nobuhisa、Niimi Kaoru、Osuka Satoko、Kajiyama Hiroaki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 50 Pages: 212~217

    • DOI

      10.1111/jog.15828

    • Peer Reviewed
  • [Journal Article] Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model2023

    • Author(s)
      Oda Yukari、Niimi Kaoru、Yoshida Kosuke、Tamauchi Satoshi、Yokoi Akira、Yasui Yuko、Nishiko Yuki、Shibata Mayu、Shimizu Yusuke、Yoshihara Masato、Ikeda Yoshiki、Yoshikawa Nobuhisa、Nishino Kimihiro、Yamamoto Eiko、Kajiyama Hiroaki
    • Journal Title

      BMC Cancer

      Volume: 23 Pages: -

    • DOI

      10.1186/s12885-023-11626-3

    • Peer Reviewed
  • [Presentation] 革新的エクソソーム回収テクノロジーを利用した新しいLiquid Biopsy戦略2024

    • Author(s)
      横井 暁
    • Organizer
      第8回 Liquid, Biopsy 研究会
    • Invited
  • [Presentation] Malignant Mechanisms of Intercellular Communication in Gynecologic Cancers2023

    • Author(s)
      Akira Yokoi
    • Organizer
      8th Biennial Meeting of Asian Society of Gynecologic Oncology (ASGO 2023)
    • Int'l Joint Research / Invited
  • [Presentation] 空間的腹水中エクソソーム解析による新しい卵巣がん進展メカニズム解析2023

    • Author(s)
      横井 暁
    • Organizer
      第65回日本婦人科腫瘍学会
    • Invited
  • [Presentation] Translational Research for Extracellular Vesicles in Ovarian Carcinoma2023

    • Author(s)
      Akira Yokoi
    • Organizer
      第65回日本婦人科腫瘍学会
    • Invited
  • [Presentation] 卵巣がんにおける細胞外小胞エクソソームの包括的機能解析2023

    • Author(s)
      横井 暁
    • Organizer
      第75回 日本産科婦人科学会学術講演会
    • Invited

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Published: 2024-12-25  

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