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2023 Fiscal Year Annual Research Report

眼球内細胞学の確立:基礎から臨床までのシームレスな研究

Research Project

Project/Area Number 21H03095
Research InstitutionKagoshima University

Principal Investigator

坂本 泰二  鹿児島大学, 医歯学域医学系, 教授 (10235179)

Co-Investigator(Kenkyū-buntansha) 原 博満  鹿児島大学, 医歯学域医学系, 教授 (20392079)
寺崎 寛人  鹿児島大学, 医歯学域鹿児島大学病院, 講師 (20746888)
橋口 照人  鹿児島大学, 医歯学域医学系, 教授 (70250917)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords人工知能 / 眼底観察 / 網膜 / 脈絡膜 / OCT
Outline of Annual Research Achievements

過去20年間、眼球内生物学研究として眼内のホメオスタシスについての研究を行ってきた。ただし、その成果の実用化は困難であった。そこで、最終年度は人工知能を用いて、その実用化を図った。我々は脈絡膜血管走行には特定のパターンがあることがOCT-en face画像解析の過程でわかったので、そのパターン認識にmachine learningを用いた。大きな進歩であったが、人工知能の思考過程が不明という問題を克服できなかった。そのため、人間との比較を行った結果、人工知能が迷う点と人間が迷う点が一致することがわかった。つまり人工知能は何も特別な思考経路を経て診断するのではなく、人間と同じような経路を示すことが解明された。この点を考えると、人工知能-画像診断の思考過程における数値は人間の自信を表すことになる。そこで、その視点から人工知能を用いて病変を描出する方法を考案した。従来の方法では、大量のGPUを消費する必要があった。そこで画像のピクセルに内包される数値を人工知能のconfidenceとして画像と重ねることで、人間が診断に迷う所を指摘するという画期的な診断装置を開発することに成功した。このアルゴリズムは国産メーカーの医療機器として商業機に搭載された。さらに、眼球最周辺部の血管観察システムを確立した。眼球周辺の画像を観察すると、周辺画像の歪みが補正できないために不可能であった。その補正に人工知能を導入することで、周辺血管の体積を始めて観察することができた。いずれも、基礎研究を実用化するというだけでなく、産業化に結び付けることができたという点から、画期的な研究であった。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

  • Research Products

    (32 results)

All 2024 2023

All Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 20 results,  Open Access: 20 results) Presentation (12 results) (of which Int'l Joint Research: 11 results,  Invited: 3 results)

  • [Journal Article] Effects of age and axial length on choroidal stratified structure in normal eyes2024

    • Author(s)
      Ito Yuki、Endo Hiroaki、Kase Satoru、Takahashi Mitsuo、Sonoda Shozo、Sakoguchi Tomonori、Sakamoto Taiji、Ishida Susumu、Kase Manabu
    • Journal Title

      Scientific Reports

      Volume: 14 Pages: -

    • DOI

      10.1038/s41598-024-52627-x

    • Peer Reviewed / Open Access
  • [Journal Article] Japan-epiretinal membrane (J-ERM) registry: A prospective cohort study protocol investigating the surgical outcome of epiretinal membrane2024

    • Author(s)
      Kanzaki Yuki、Matoba Ryo、Ishihara Kenji、Morita Tetsuro、Muraoka Yuki、Kimura Shuhei、Koto Takashi、Kawasaki Ryo、Baba Takayuki、Okamoto Fumiki、Inoue Makoto、Sakamoto Taiji、Tsujikawa Akitaka、Morizane Yuki
    • Journal Title

      PLOS ONE

      Volume: 19 Pages: e0297347

    • DOI

      10.1371/journal.pone.0297347

    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and Safety of Faricimab for Macular Edema due to Retinal Vein Occlusion2024

    • Author(s)
      Tadayoni Ramin、Paris Liliana P.、Danzig Carl J.、Abreu Francis、Khanani Arshad M.、Brittain Christopher、Lai Timothy Y.Y.、Haskova Zdenka、Sakamoto Taiji、Kotecha Aachal、Schlottmann Patricio G.、Liu Ying、Seres Andr?s、Retiere Anne-Cecile、Willis Jeffrey R.、Yoon Young Hee
    • Journal Title

      Ophthalmology

      Volume: - Pages: -

    • DOI

      10.1016/j.ophtha.2024.01.029

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] VEGF-A165 is the predominant VEGF-A isoform in platelets, while VEGF-A121 is abundant in serum and plasma from healthy individuals2023

    • Author(s)
      Yamakuchi Munekazu、Okawa Masashi、Takenouchi Kazunori、Bibek Aryal、Yamada Shingo、Inoue Keiichi、Higurashi Kazuhiko、Tabaru Akito、Tanoue Kiyonori、Oyama Yoko、Higashi Sadayuki、Fujisaki Chieko、Kanda Hideaki、Terasaki Hiroto、Sakamoto Taiji、Soga Yoshiharu、Hashiguchi Teruto
    • Journal Title

      PLOS ONE

      Volume: 18 Pages: e0284131

    • DOI

      10.1371/journal.pone.0284131

    • Peer Reviewed / Open Access
  • [Journal Article] Vortex Veins in Eyes With Pachychoroid Spectrum Disorders Evaluated by the Adjusted Reverse 3-Dimensional Projection Model2023

    • Author(s)
      Funatsu Ryoh、Sonoda Shozo、Terasaki Hiroto、Shiihara Hideki、Hirokawa Mariko、Yuanting Ji、Tanabe Yasushi、Sakamoto Taiji
    • Journal Title

      Ophthalmology Science

      Volume: 3 Pages: 100320~100320

    • DOI

      10.1016/j.xops.2023.100320

    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Duration of Macular Detachment on Visual Prognosis after Surgery for Macula-Off Retinal Detachment2023

    • Author(s)
      Miyake Masahiro、Nakao Shin-ya、Morino Kazuya、Yasukura Shota、Mori Yuki、Ishihara Kenji、Muraoka Yuki、Miyata Manabu、Tamura Hiroshi、Sakamoto Taiji、Tsujikawa Akitaka
    • Journal Title

      Ophthalmology Retina

      Volume: 7 Pages: 375~382

    • DOI

      10.1016/j.oret.2023.01.014

    • Peer Reviewed / Open Access
  • [Journal Article] A nationwide survey of newly certified visually impaired individuals in Japan for the fiscal year 2019: impact of the revision of criteria for visual impairment certification2023

    • Author(s)
      Matoba Ryo、Morimoto Noriko、Kawasaki Ryo、Fujiwara Miyuki、Kanenaga Keisuke、Yamashita Hidetoshi、Sakamoto Taiji、Morizane Yuki
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 67 Pages: 346~352

    • DOI

      10.1007/s10384-023-00986-9

    • Peer Reviewed / Open Access
  • [Journal Article] Changes in choriocapillaris structure occurring in idiopathic macular hole before and after vitrectomy2023

    • Author(s)
      Endo Hiroaki、Kase Satoru、Takahashi Mitsuo、Ito Yuki、Sonoda Shozo、Sakoguchi Tomonori、Sakamoto Taiji、Katsuta Satoshi、Ishida Susumu、Kase Manabu
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 261 Pages: 1901~1912

    • DOI

      10.1007/s00417-023-06004-5

    • Peer Reviewed / Open Access
  • [Journal Article] Correction: Cost-Effectiveness Analysis of Ranibizumab Biosimilar for Neovascular Age-Related Macular Degeneration in Japan2023

    • Author(s)
      Yanagi Yasuo、Takahashi Kanji、Iida Tomohiro、Gomi Fumi、Morii Junko、Kunikane Eriko、Sakamoto Taiji
    • Journal Title

      Ophthalmology and Therapy

      Volume: 12 Pages: 2821~2822

    • DOI

      10.1007/s40123-023-00788-9

    • Peer Reviewed / Open Access
  • [Journal Article] Three-year changes in sex judgment using color fundus parameters in elementary school students2023

    • Author(s)
      Yamashita Takehiro、Asaoka Ryo、Terasaki Hiroto、Yoshihara Naoya、Kakiuchi Naoko、Sakamoto Taiji
    • Journal Title

      PLOS ONE

      Volume: 18 Pages: e0295123

    • DOI

      10.1371/journal.pone.0295123

    • Peer Reviewed / Open Access
  • [Journal Article] Effect of the macular shape on hole findings in idiopathic macular hole differs depending on the stage of the macular hole2023

    • Author(s)
      Terasaki Hiroto、Yamashita Toshifumi、Funatsu Ryoh、Nomoto Shohei、Fujiwara Kazuki、Shiihara Hideki、Yamashita Takehiro、Sakamoto Taiji
    • Journal Title

      Scientific Reports

      Volume: 13 Pages: -

    • DOI

      10.1038/s41598-023-42509-z

    • Peer Reviewed / Open Access
  • [Journal Article] A Photodynamic Therapy Index for Central Serous Chorioretinopathy to Predict Visual Prognosis Using Pretreatment Factors2023

    • Author(s)
      FUNATSU RYOH、TERASAKI HIROTO、SONODA SHOZO、SHIIHARA HIDEKI、MIHARA NAOHISA、SAKAMOTO TAIJI
    • Journal Title

      American Journal of Ophthalmology

      Volume: 253 Pages: 86~95

    • DOI

      10.1016/j.ajo.2023.04.016

    • Peer Reviewed / Open Access
  • [Journal Article] The impact of artificial intelligence on retinal disease management: Vision Academy retinal expert consensus2023

    • Author(s)
      Danese Carla、Kale Aditya U.、Aslam Tariq、Lanzetta Paolo、Barratt Jane、Chou Yu-Bai、Eldem Bora、Eter Nicole、Gale Richard、Kozak Igor、Li Xiaorong、Li Xiaoxin、Loewenstein Anat、Ruamviboonsuk Paisan、Sakamoto Taiji、et al.
    • Journal Title

      Current Opinion in Ophthalmology

      Volume: 34 Pages: 396~402

    • DOI

      10.1097/ICU.0000000000000980

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Current status and practical considerations of artificial intelligence use in screening and diagnosing retinal diseases: Vision Academy retinal expert consensus2023

    • Author(s)
      Chou Yu-Bai、Kale Aditya U.、Lanzetta Paolo、Aslam Tariq、Barratt Jane、Danese Carla、Eldem Bora、Eter Nicole、Gale Richard、Kozak Igor、Li Xiaorong、Li Xiaoxin、Loewenstein Anat、Ruamviboonsuk Paisan、Sakamoto Taiji、et al.
    • Journal Title

      Current Opinion in Ophthalmology

      Volume: 34 Pages: 403~413

    • DOI

      10.1097/ICU.0000000000000979

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-VEGF Treatment Strategies for 3 Subtypes of Neovascular Age-Related Macular Degeneration in a Clinical Setting2023

    • Author(s)
      Yoneda Keisuke、Takeuchi Masaru、Yasukawa Tsutomu、Terasaki Hiroto、Yamamoto Yuki、Jujo Tatsuya、Wakuta Makiko、Matsubara Hisashi、Mitamura Yoshinori、Kato Aki、Kondo Mineo、Kimura Kazuhiro、Takagi Hitoshi、Gomi Fumi、Sakamoto Taiji
    • Journal Title

      Ophthalmology Retina

      Volume: 7 Pages: 869~878

    • DOI

      10.1016/j.oret.2023.06.002

    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Characteristics and Progression of Geographic Atrophy in a Japanese Population2023

    • Author(s)
      Sato Yukiko、Ueda-Arakawa Naoko、Takahashi Ayako、Miyara Yasunori、Hara Chikako、Kitajima Yoko、Maruko Ruka、Kawai Moeko、Takahashi Hajime、Koizumi Hideki、Kawasaki Ryo、Maruyama-Inoue Maiko、Yanagi Yasuo、Iida Tomohiro、Takahashi Kanji、Sakamoto Taiji、Tsujikawa Akitaka
    • Journal Title

      Ophthalmology Retina

      Volume: 7 Pages: 901~909

    • DOI

      10.1016/j.oret.2023.06.004

    • Peer Reviewed / Open Access
  • [Journal Article] Cost-Effectiveness Analysis of Ranibizumab Biosimilar for Neovascular Age-Related Macular Degeneration in Japan2023

    • Author(s)
      Yanagi Yasuo、Takahashi Kanji、Iida Tomohiro、Gomi Fumi、Morii Junko、Kunikane Eriko、Sakamoto Taiji
    • Journal Title

      Ophthalmology and Therapy

      Volume: 12 Pages: 2005~2021

    • DOI

      10.1007/s40123-023-00715-y

    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics Related to Visual Acuity Loss After Successful Photodynamic Therapy for Eyes With Central Serous Chorioretinopathy2023

    • Author(s)
      Funatsu Ryoh、Terasaki Hiroto、Sonoda Shozo、Shiihara Hideki、Mihara Naohisa、Sakamoto Taiji
    • Journal Title

      American Journal of Ophthalmology

      Volume: 256 Pages: 164~174

    • DOI

      10.1016/j.ajo.2023.05.022

    • Peer Reviewed / Open Access
  • [Journal Article] Colour tone of retinal arterioles imaged with a colour scanning laser ophthalmoscope can be an indicator of systemic arterial stiffness2023

    • Author(s)
      Sakono Takato、Terasaki Hiroto、Kubozono Takuro、Sonoda Shozo、Funatsu Ryoh、Mihara Naohisa、Shiihara Hideki、Ohishi Mitsuru、Sakamoto Taiji
    • Journal Title

      BMJ Open Ophthalmology

      Volume: 8 Pages: e001456

    • DOI

      10.1136/bmjophth-2023-001456

    • Peer Reviewed / Open Access
  • [Journal Article] Quantification of peripapillary nerve fibre elevation and its association with axial length, optic disc tilt, and parapapillary atrophy area in young, healthy eyes2023

    • Author(s)
      Fujiwara Kazuki、Yamashita Takehiro、Terasaki Hiroto、Nakao Kumiko、Sakamoto Taiji
    • Journal Title

      Eye

      Volume: 38 Pages: 1112~1117

    • DOI

      10.1038/s41433-023-02827-y

    • Peer Reviewed / Open Access
  • [Presentation] A PDT index for central serous chorioretinopathy to predict visual prognosis by pretreatment factors2023

    • Author(s)
      Taiji Sakamoto
    • Organizer
      Retina China 2023 and the 24th International Retina Forum
    • Int'l Joint Research / Invited
  • [Presentation] Next Generation AI: Wayfinding AI to Detect Uncertain Spot of OCT Image in Retinal Diseases2023

    • Author(s)
      Taiji Sakamoto
    • Organizer
      Taiwan Macula Society Annual Meeting 2023
    • Int'l Joint Research / Invited
  • [Presentation] A PDT Index for Central Serous Chorioretinopathy to Predict Visual Prognosis by Pretreatment Factors2023

    • Author(s)
      Taiji Sakamoto
    • Organizer
      Taiwan Macula Society Annual Meeting 2023
    • Int'l Joint Research / Invited
  • [Presentation] Real-world Study of Faricimab and PDS With Ranibizumab in nAMD and DME.2023

    • Author(s)
      坂本泰二,石田晋,安川力,河野美佳,鈴木智之,Gloria C. Chi, Stefan Scheidl, Monica Bengus, Robyn Guymer:VOYAGER
    • Organizer
      第127回日本眼科学会総会
  • [Presentation] Characteristics of three types of neovascular age-related macular degeneration and treatment strategies of anti-VEGF agents in real-world clinical setting: A multicenter cohort study by J-CREST2023

    • Author(s)
      Yoneda K, Yasukawa T, Terasaki H, Yamamoto Y, Jujo T, Wakuta M, Matsubara H, Mitamura Y, Katou A, Kondo M, Kimura K, Takagi H, Gomi F, Sakamoto T, Takeuchi M
    • Organizer
      ARVO 2023
    • Int'l Joint Research
  • [Presentation] Real-world management of treatment-nave diabetic macular edema after the approval of anti-VEGF therapy in Japan: 2-year visual outcome focusing on the starting year of intervention from STREAT-DME 2 study.2023

    • Author(s)
      Shimura M, Kitano S, Sakamoto T
    • Organizer
      ARVO 2023
    • Int'l Joint Research
  • [Presentation] ex and Generation Dependent Widefield Choroidal Thickness Differences in Healthy eyes.2023

    • Author(s)
      Mihara N, Sonoda S, Terasaki H, Funatsu R, Sakamoto T
    • Organizer
      ARVO 2023
    • Int'l Joint Research
  • [Presentation] Characteristics associated with visual acuity loss after photodynamic therapy for central serous chorioretinopathy.2023

    • Author(s)
      Funatsu R, Terasaki H, Sonoda S, Shiihara H, Mihara N, Sakamoto T
    • Organizer
      ARVO 2023
    • Int'l Joint Research
  • [Presentation] Relationship between acceleration of axial elongation and ocular biometry in children.2023

    • Author(s)
      Yamashita T, Sakamoto T
    • Organizer
      ARVO 2023
    • Int'l Joint Research
  • [Presentation] Prediction of systemic arteriosclerosis using fundus images from a color laser scanning ophthalmoscope.2023

    • Author(s)
      Terasaki H, Sakono T, Funatsu R, Sonoda S, Sakamoto T
    • Organizer
      ARVO 2023
    • Int'l Joint Research
  • [Presentation] Color tone of retinal arterioles imaged with a color scanning laser ophthalmoscope can be an indicator of systemic arterial stiffness.2023

    • Author(s)
      Sakono T, Terasaki H, Kubozono T, Sonoda S, Funatsu R, Mihara N, Shiihara H, Ohishi M, Sakamoto T
    • Organizer
      ARVO 2023
    • Int'l Joint Research
  • [Presentation] A photodynamic therapy index for central serous chorioretinopathy to predict visual prognosis using pretreatment factors.2023

    • Author(s)
      Sakamoto T, Funatsu R
    • Organizer
      The Retina Society 56th Annual Scientific Meeting
    • Int'l Joint Research

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Published: 2024-12-25  

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