Studying for mechanism of senescence activity in skin appendage development

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H03122
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Niigata University
• Principal Investigator: Ohazama Atsushi 新潟大学, 医歯学系, 教授 (40266169)
• Co-Investigator(Kenkyū-buntansha): 前田 健康 新潟大学, 医歯学系, 教授 (40183941) ; 川崎 真依子 新潟大学, 医歯学系, 准教授 (40584587)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 老化 / 器官形成

Outline of Final Research Achievements

Teeth regeneration require the use of stem cells. However, it remains unclear how stem cells are directed into tooth forming cells. Teeth and hair belong to skin appendages. All skin appendages are absent in some genetic disease, which indicate that embryonic cells differentiate into tooth forming cells after determining their fate as skin appendages, but not direct differentiation into tooth germ cells from embryonic cells. We found senescence in skin appendage development. The expression pattern and its intensity were differed between stage in same organ, and between organs.

Free Research Field

発生生物学

Academic Significance and Societal Importance of the Research Achievements

歯の再生は、２１世紀で成し遂げるべき医療であり、その実現には幹細胞の利用が必要となる。そのためには、幹細胞の歯胚細胞への正しい分化誘導法の理解が欠かせない。歯は皮膚の付属器官の一つである。本研究では、皮膚の付属器官の発生器官中に老化シグナルが発現することを見出した。本研究成果は、幹細胞を用いた歯の発生治療の確立に大きく貢献できる。