2023 Fiscal Year Final Research Report
The effect of heavy metal exposure in fetal period on the biomarkers of cardiometabolic diseases and immune cells
| Project/Area Number |
21H03177
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 慢性重金属暴露 / ヒ素 / カドミウム / 胎児期 / 心代謝バイオマーカー / 免疫 |
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| Outline of Final Research Achievements |
Few studies have examined cardiometabolic disease prognosis from childhood exposure to toxic metals. This study aimed to evaluate the effects of chronic exposure to arsenic and cadmium on immune cell types and cardiometabolic disease biomarkers in peripheral blood. The study was evaluated at age 15 in a birth cohort of a nutritional supplementation trial conducted on pregnant women. Urinary total arsenic and cadmium concentrations were measured by HVG-AAS. Peripheral blood mononuclear cells were isolated and phenotypically analyzed by flow cytometry. The results suggest that chronic arsenic exposure in 15-year-old adolescents in rural Bangladesh is associated with an imbalance in the cellular immune response and also with changes in plasma lipids.
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| Free Research Field |
臨床疫学、公衆衛生学
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| Academic Significance and Societal Importance of the Research Achievements |
慢性疾患(non-communicable disease: NCD)の発症に対する環境毒物曝露の影響は、これまでの研究ではあまり重要視されていなかった。 WHOは、NCD罹患の多くが途上国からの報告であり、今後も増大することを予測している。NCDを効果的に予防するには、その原因となるメカニズムを広い範囲で理解する必要がある。飲料水や食品などによる有毒金属の胎児期から幼少期における暴露の影響が明らかになれば、リスク軽減するための効果的な措置を講じることができる。
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