2023 Fiscal Year Final Research Report
Development for Personalized Medicine for Atherosclerotic Cardiovascular Disease based on Genomic Information and Lifestyle Habits
| Project/Area Number |
21H03179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野村 章洋 金沢大学, 融合科学系, 准教授 (30707542)
多田 隼人 金沢大学, 附属病院, 助教 (90623653)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 動脈硬化性疾患個別化医療 |
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| Outline of Final Research Achievements |
(1) Development of cardiovascular disease-related PRS in East Asia:Compared to Europe and the United States, including East Asia and Oceania, we reported that the number of studies on GWAS, which is indispensable for the calculation of PRS, is extremely small relative to the population.
(2) Personalized medicine for familial hypercholesterolemia:In familial hypercholesterolemia, coronary artery calcium scores from coronary CT examination were strongly associated with arteriosclerotic disease as well as genetic background. In addition, in addition to congenital factors (genetic background), acquired lifestyle habits were associated with risk stratification of arteriosclerotic disease.
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| Free Research Field |
分子遺伝学
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| Academic Significance and Societal Importance of the Research Achievements |
現状において東アジアおよびオセアニア地域を含めて欧州や米国と比較し、人口比に対して極めて研究数が少ないという実態を明らかとした。また、遺伝的背景の評価と同時に冠動脈CTなどの非侵襲的検査を加えることで、動脈硬化性疾患のリスク層別化に繋がることを示すとともに先天的要因（遺伝的背景）に加えて後天的生活習慣が、動脈硬化性疾患のリスク層別化と関連することを明らかとした。
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