• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Final Research Report

Establishment of a new exercise therapy for osteoarthritis using HIF-1alpha regulation by hypoxia

Research Project

  • PDF
Project/Area Number 21H03295
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Arai Yuji  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (50347449)

Co-Investigator(Kenkyū-buntansha) 松田 修  京都府立医科大学, 医学(系)研究科(研究院), 教授 (00271164)
岸田 綱郎  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00370205)
高橋 謙治  京都府立医科大学, 医学(系)研究科(研究院), 教授 (30347447)
中川 周士  京都府立医科大学, 医学(系)研究科(研究院), 助教 (30643382)
Project Period (FY) 2021-04-01 – 2024-03-31
KeywordsHIF-1α / 変形性膝関節症 / 低酸素環境 / 運動療法
Outline of Final Research Achievements

We examined the effects of hypoxic condition on cartilage in vivo. First, we determined 12% oxygen concentration which rats can be bred normally. Next, we bred rats OA model under 12% oxygen or normoxia for 4 weeks, but there was no significant difference. We considered this to be an effect of negative feedback due to sustained hypoxia, so changed to intermittent hypoxia. rats OA model were bred under 12% oxygen and normoxia every other day for a total of 4 weeks, and histological examination of the knee joints. Cartilage wear and Mankin score were significantly improved in the intermittent hypoxia group. We need further investigation of condition settings, including in vitro studies.

Free Research Field

運動器

Academic Significance and Societal Importance of the Research Achievements

運動療法は変形性関節症(osteoarthritis; OA)に対する有効な保存療法である。また低酸素環境では、低酸素誘導因子hypoxia-inducible factor(HIF)-1αの発現を介して軟骨細胞は恒常性を維持している。低酸素環境下運動療法で、関節軟骨のHIF-1αを賦活化させることにより効率的にOAを予防・治療できるのではないかと考え、まずは低酸素環境の条件の検討を行った。間欠的な低酸素環境において軟骨変性は有意に抑制されていた。今後、in vitroにおける検討および骨格筋に対しても同様にanabolicな効果をもたらすか等の検討を進めていく必要がある。

URL: 

Published: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi