Molecular Cell Biology of Fatigue Mechanisms Approached from Developmental Studies of Cellular Stress and Inflammation

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H03334
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Kanazawa Medical University
• Principal Investigator: IWAWAKI Takao 金沢医科大学, 総合医学研究所, 教授 (50342754)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 疲労 / 睡眠 / 運動 / 細胞ストレス / 炎症

Outline of Final Research Achievements

Fatigue, along with fever and pain, is one of the three major biological alarms, and is an important signal given by the body to maintain life and health. However, research and understanding of fatigue has lagged behind that of fever and pain, and even in today's advanced scientific age, the actual state of fatigue is not well understood. The principal investigator has been involved in research on cellular stress and inflammation in experimental systems using mice, and has come to the hypothesis that these factors are involved in fatigue. In this study, we first established a mouse experimental system for fatigue research. Next, we are elucidating the possibility that cellular stress and inflammation are involved in the generation/recovery of fatigue based on in vivo imaging analysis.

Free Research Field

分子細胞生物学

Academic Significance and Societal Importance of the Research Achievements

疲労に苦しむ人々は非常に多く、これは現代社会において決して無視できない大きな問題であり、その解決の新たな糸口となることを目指して本研究に取り組んだ。特に重要なのは、この研究から明らかになることが単に基礎的な生命科学へ貢献するだけでなく、疲労が生む社会問題（健康障害から事故・自殺に至るまで）の解決へ繋がる可能性を十分に含んでいることである。