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2023 Fiscal Year Final Research Report

Elucidation of human body function using upright CT ~Looking at the era of healthy longevity~

Research Project

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Project/Area Number 21H03799
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionKeio University

Principal Investigator

Jinzaki Masahiro  慶應義塾大学, 医学部(信濃町), 教授 (80216259)

Co-Investigator(Kenkyū-buntansha) 秋田 大宇  慶應義塾大学, 医学部(信濃町), 講師 (10383697)
橋本 正弘  慶應義塾大学, 医学部(信濃町), 助教 (20528393)
山田 稔  慶應義塾大学, 医学部(信濃町), 特任准教授 (60365434)
山田 祥岳  慶應義塾大学, 医学部(信濃町), 准教授 (60383791)
稲本 陽子  藤田医科大学, 保健学研究科, 教授 (70612547)
秋田 恵一  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80231819)
大竹 義人  奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (80349563)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords立位 / 嚥下機能 / 排尿機能 / 運動機能
Outline of Final Research Achievements

In the era of health and longevity, we aimed to promote the early detection and elucidation of functional disorders. To achieve this, we conducted research on the mechanisms of three functions: swallowing, urination, and walking. For swallowing function, we had a specialized chair designed, and developed a protocol for scanning and established a method for this examination. For urination function, we established a scanning protocol, and clarified the mechanism of normal urination. Imaging of patient groups revealed three patterns of urination disorders (benign prostatic hyperplasia, bladder neck sclerosis, neurogenic bladder). Thus, evaluating urination function appears useful in devising treatment strategies. Concerning walking function, the relation with posture was deemed significant, and software for objectively evaluating posture was developed. Additionally, software capable of measuring muscle volume with a 5% margin of error was developed, deemed useful in predicting frailty.

Free Research Field

放射線医学

Academic Significance and Societal Importance of the Research Achievements

これまで嚥下、排尿、姿勢や筋肉量などの運動機能は、画像では評価ができなかった。これらの撮影法が確立できたことは、今後これらの機能を定量化していける道を切り開いたという意味で非常に意義が高いと考える。また、排尿においては、治療方針の決定を左右する病態をこの手法で明らかにできることを明らかにでき、患者への有用性を明確にできた。
また、立位CTが新たに4台の導入が決まっていることも、社会的に有用性を認知され始めたことを意味していると考える。

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Published: 2025-01-30  

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