2023 Fiscal Year Final Research Report
Generation of novel bimolecular functions with artificial chaperone engineering
| Project/Area Number |
21H03816
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 90120:Biomaterials-related
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | artificial chaperone / oligonucleotides / peptides / lipid membrane / folding / molecular assembly / graft copolymer |
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| Outline of Final Research Achievements |
The objective of this research project is to significantly enhance the functions of biopolymer and create new functions through the construction of polymer nano-materials, thereby innovatively advancing medical engineering devices. The expression of biopolymer functions relies heavily on their higher-order structural formation and organization. Furthermore, transitions between different structures play a fundamental role in advanced biological functions such as signal transduction, substance transport, and substance synthesis. We have pioneered a method for designing synthetic polymers that promote structural formation and functions of biopolymers, known as "chaperone activity," focusing on the ionic properties of biomolecules such as nucleic acids and peptides.
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| Free Research Field |
生体機能性材料
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、生体分子の高次構造を制御し得る人工シャペロン高分子材料を、様々な生体機能の強化手法として先鋭かつ広く展開するとともに、高い次元で厳密かつ柔軟に組織化可能な特徴を活用し、生体分子のみでは実現不可能な新たな機能創出につなげ、診断・治療の革新的発展の促す基盤材料として発展させた。例えば、診断・治療法のツールとして期待されている核酸酵素の活性や核酸分子コンピューターや核酸自己組織化反応も迅速化に人工シャペorン材料が有用である事を見いだした。また、人工シャペロン材料は、膜活性ペプチドなどの機能性ペプチドの高機能化に有用である事も見いだした。
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