• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Final Research Report

Development of prevention and treatment methods using the RFS Index in refeeding syndrome

Research Project

  • PDF
Project/Area Number 21K02093
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionUniversity of Hyogo

Principal Investigator

Sarasa Tanaka  兵庫県立大学, 環境人間学部, 助教 (90733387)

Project Period (FY) 2021-04-01 – 2024-03-31
Keywordsリフィーディングシンドローム / 低リン血症 / 血液メタボローム
Outline of Final Research Achievements

Refeeding syndrome (RFS), which develops when active nutritional supplementation is started in patients in a chronically malnourished state, is a fatal metabolic disorder, but active prevention and treatment methods for RFS have not been established.
In this study, we focused on the biological state before the onset of RFS and identified four types of candidate substances related to the onset of RFS through blood metabolome analysis. When the candidate substances related to the onset were administered to an already established RFS model animal, an RFS onset preventive effect was suggested. In addition, in order to find factors that affect the onset of RFS, we clarified the relationship between the onset of RFS and diabetes, aging, administration method, etc. It is expected that these results will lead to the development of nutritional prevention and treatment methods for RFS in the future.

Free Research Field

臨床栄養学

Academic Significance and Societal Importance of the Research Achievements

リフィーディングシンドローム(RFS)は慢性的な低栄養状態にある患者において発症する致死的な症候群である。現代の日本においては、超高齢化のため低栄養患者が増加しており、それに伴いRFS患者は増加している。しかしながら、発症メカニズムは不明であり、積極的な治療・予防法はない。
本研究により、RFS発症関連候補物質が見いだされ、再摂食時の投与により一定のRFS予防効果が明らかとなった。また、糖尿病、加齢、栄養投与法が発症に関与する可能性が示された。今後の更なる研究により、RFS発症メカニズムの解明および予防、治療法の開発の一助となることが期待される。

URL: 

Published: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi