Elucidation of a novel mechanism for the development of hyperLDLemia in diabetes mellitus and its improvement by food-derived ingredients.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K02110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 08030:Family and consumer sciences, and culture and living-related
• Research Institution: University of Niigata Prefecture
• Principal Investigator: Hagiwara Makoto 新潟県立大学, 人間生活学部, 助教 (30546099)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 糖尿病 / 高血糖 / エンドサイトーシス / LDLコレステロール / Rab5 / 炎症 / MAPK

Outline of Final Research Achievements

Diabetes mellitus is one of the major diseases defined by the Ministry of Health, Labor and Welfare. Diabetes increases the risk of hyperLDL hematosis, a condition in which blood levels of LDL cholesterol are high. HyperLDLemia has been reported to promote atherosclerosis formation and cause cardiac disease and stroke. In a human study, 70% of diabetic patients died of cardiac disease and stroke. This study aims to elucidate the mechanism of hyperLDLemia development in diabetes mellitus and to examine methods of improving hyperLDLemia with food-derived ingredients. The applicant's research has found that high glucose decreases LDL endocytosis and that certain food-derived components improve hyperLDLemia by increasing endocytotic activity.

Free Research Field

栄養生化学

Academic Significance and Societal Importance of the Research Achievements

糖尿病有病者は、循環器疾患で亡くなる割合が多い。本研究によって、糖尿病における高LDL血症発症のメカニズムが明らかになるとともに、エンドサイトーシス活性を上昇させることによって、高LDL血症を改善する可能性のある食品由来成分を見つけ出した。本研究によって明らかになったメカニズムはこれまでに報告がなく、新たな切り口でこのメカニズムをターゲットとすることによって、糖尿病における高LDL血症を予防・改善する方法が確立されることが期待される。